Abstract
Background
Ear squamous cell carcinoma (SCC) is a tumor with a poor prognosis, due to a late initial diagnosis because of a concealment by primarily benign symptoms and due to the unfavorable localization including the infiltration of important structures such as the middle ear, mandibular joint or dura.
Patients and methods
We retrospectively examined 10 patients, medium age: 63.8 ± 9.3 years between 2002 and 2008 with a histological confirmed SCC of the external auditory canal. The median follow-up period was 20.5 months (range 7–60 months).
Results
The treatment involving surgery, radiotherapy and/or chemotherapy yielded a survival rate of 38.3 ± 11.3 months for T1 and a survival rate of 17.0 ± 3.0 months for T2–T4 tumors. 3/10 patients at T1 stage are under follow-up, all 7/10 (70%) patients at T2 and T4 stage did not survive 5 years.
Conclusion
The prognosis for ear SCC primarily depends on early clinical and histopathological diagnostics and requires a sufficient and standardized staging to determine the therapy involving surgery and radiochemotherapy.
Keywords: Carcinoma of the external auditory canal, Squamous cell carcinoma, Surgery, Radiation treatment, Prognosis
Full Text
The Full Text of this article is available as a PDF (229.5 KB).
References
- 1.Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL (1991) Saunders, Philadelphia, London, pp 1253–1254
- 2.Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL (1991) Saunders, Philadelphia, London, pp 1253–1254
- 3.Crabtree J.A., Britton B.H., Pierce M.K. Carcinoma of the external auditory canal. Laryngoscope. 1976;86:405–415. doi: 10.1288/00005537-197603000-00010. [DOI] [PubMed] [Google Scholar]
- 4.Ußmüller J., Hartwein J., Rauchfuß A., et al. Primary carcinoma in the auditory canal. Clinical picture, intratemporal growth patterns and operative strategy. HNO. 2001;49:256–263. doi: 10.1007/s001060050743. [DOI] [PubMed] [Google Scholar]
- 5.Shu M.T., Lin H.C., Yang C.C., et al. Squamous cell carcinoma in situ of the external auditory canal. J Laryngol Otol. 2006;120:684–686. doi: 10.1017/S0022215106001538. [DOI] [PubMed] [Google Scholar]
- 6.Kinney S.E., Wood B.G. Malignancies of the external ear canal and temporal bone: Surgical techniques and results. Laryngoscope. 1987;97:158–164. doi: 10.1288/00005537-198702000-00006. [DOI] [PubMed] [Google Scholar]
- 7.Stell P.M. Carcinoma of the external auditory meatus and middle ear. Clin Otolaryngol. 1984;9:281–299. doi: 10.1111/j.1365-2273.1984.tb01511.x. [DOI] [PubMed] [Google Scholar]
- 8.Arriaga M., Curtin H., Takahashi H., et al. Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings. Ann Otol Rhinol Laryngol. 1990;99:714–721. doi: 10.1177/000348949009900909. [DOI] [PubMed] [Google Scholar]
- 9.Moody S.A., Hirsch B.E., Myers E.N. Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol. 2000;21:582–588. [PubMed] [Google Scholar]
- 10.Grandis J.R., Hirsch B.E., Yu V.L. Simultaneous presentation of malignant external otitis and temporal bone cancer. Arch Otolaryngol Head Neck Surg. 1993;119:687–689. doi: 10.1001/archotol.1993.01880180107021. [DOI] [PubMed] [Google Scholar]
- 11.Schwager K., Pfreundner L., Hoppe F., et al. Carcinoma of the External Auditory Canal and Middle Ear as an Interdisciplinary Challenge for Otosurgery and Radiotherapy. Laryngo-Rhino-Otol. 2001;80:196–202. doi: 10.1055/s-2001-13765. [DOI] [PubMed] [Google Scholar]
- 12.Kinney S.E. Squamous cell carcinoma of the external auditory canal. Am J Otol. 1989;1:111–116. [PubMed] [Google Scholar]
- 13.Shih L., Crabtree J.A. Carcinoma of the external auditory canal: an update. Laryngoscope. 1990;100:1215–1218. doi: 10.1288/00005537-199011000-00016. [DOI] [PubMed] [Google Scholar]
- 14.Nyrop M., Grontved A. Cancer of the External Auditory Canal. Arch Otolaryngol Head Neck Surg. 2002;128:834–837. doi: 10.1001/archotol.128.7.834. [DOI] [PubMed] [Google Scholar]
- 15.Lobo D., Llorente J.L., Suarez C. Squamous cell carcinoma of the external auditory canal. Skull Base. 2008;18:167–172. doi: 10.1055/s-2007-994290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Stell P.M., McCormick M.S. Carcinoma of the external auditory meatus and middle ear. J Laryngol Otol. 1985;99:847–850. doi: 10.1017/S0022215100097796. [DOI] [PubMed] [Google Scholar]
- 17.Lederman M. Malignant tumours of the ear. J Laryngol Otol. 1965;79:85–129. doi: 10.1017/s0022215100063465. [DOI] [PubMed] [Google Scholar]
- 18.Gacek R.R., Goodman M. Management of malignancy of the temporal bone. Laryngoscope. 1977;87:1622–1634. doi: 10.1288/00005537-197710000-00003. [DOI] [PubMed] [Google Scholar]
- 19.Arena S., Keen M. Carcinoma of the middle ear and temporal bone. Am J Otol. 1988;9:351–356. [PubMed] [Google Scholar]