Abstract
1H NMR was used to monitor lactate production and clearance during hypoxemia and recovery in the rabbit brain at the relatively low magnetic-field strength of 1.89 T. An array of conventional physiological variables were recorded simultaneously with spectrum acquisition, including the electroencephalogram and electrocardiogram. The sensitivity and spectral resolution achieved at this field strength should be applicable to studies of human brain pathophysiology in the large-bore magnets now available.
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- Behar K. L., den Hollander J. A., Stromski M. E., Ogino T., Shulman R. G., Petroff O. A., Prichard J. W. High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc Natl Acad Sci U S A. 1983 Aug;80(16):4945–4948. doi: 10.1073/pnas.80.16.4945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown F. F., Campbell I. D., Kuchel P. W., Rabenstein D. C. Human erythrocyte metabolism studies by 1H spin echo NMR. FEBS Lett. 1977 Oct 1;82(1):12–16. doi: 10.1016/0014-5793(77)80875-2. [DOI] [PubMed] [Google Scholar]
- Bydder G. M., Steiner R. E., Young I. R., Hall A. S., Thomas D. J., Marshall J., Pallis C. A., Legg N. J. Clinical NMR imaging of the brain: 140 cases. AJR Am J Roentgenol. 1982 Aug;139(2):215–236. doi: 10.2214/ajr.139.2.215. [DOI] [PubMed] [Google Scholar]
- Cady E. B., Costello A. M., Dawson M. J., Delpy D. T., Hope P. L., Reynolds E. O., Tofts P. S., Wilkie D. R. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet. 1983 May 14;1(8333):1059–1062. doi: 10.1016/s0140-6736(83)91906-2. [DOI] [PubMed] [Google Scholar]
- Chance B., Nakase Y., Bond M., Leigh J. S., Jr, McDonald G. Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays. Proc Natl Acad Sci U S A. 1978 Oct;75(10):4925–4929. doi: 10.1073/pnas.75.10.4925. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Delpy D. T., Gordon R. E., Hope P. L., Parker D., Reynolds E. O., Shaw D., Whitehead M. D. Noninvasive investigation of cerebral ischemia by phosphorus nuclear magnetic resonance. Pediatrics. 1982 Aug;70(2):310–313. [PubMed] [Google Scholar]
- Fleming M. C., Lowry O. H. The measurement of free and N-acetylated aspartic acids in the nervous system. J Neurochem. 1966 Sep;13(9):779–783. doi: 10.1111/j.1471-4159.1966.tb05872.x. [DOI] [PubMed] [Google Scholar]
- Norwood W. I., Ingwall J. S., Norwood C. R., Fossel E. T. Developmental changes of creatine kinase metabolism in rat brain. Am J Physiol. 1983 Mar;244(3):C205–C210. doi: 10.1152/ajpcell.1983.244.3.C205. [DOI] [PubMed] [Google Scholar]
- Plum F. What causes infarction in ischemic brain?: The Robert Wartenberg Lecture. Neurology. 1983 Feb;33(2):222–233. doi: 10.1212/wnl.33.2.222. [DOI] [PubMed] [Google Scholar]
- Prichard J. W., Alger J. R., Behar K. L., Petroff O. A., Shulman R. G. Cerebral metabolic studies in vivo by 31P NMR. Proc Natl Acad Sci U S A. 1983 May;80(9):2748–2751. doi: 10.1073/pnas.80.9.2748. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pykett I. L., Buonanno F. S., Brady T. J., Kistler J. P. True three-dimensional nuclear magnetic resonance neuro-imaging in ischemic stroke: correlation of NMR, X-ray CT and pathology. Stroke. 1983 Mar-Apr;14(2):173–177. doi: 10.1161/01.str.14.2.173. [DOI] [PubMed] [Google Scholar]
- Thulborn K. R., du Boulay G. H., Duchen L. W., Radda G. A 31P nuclear magnetic resonance in vivo study of cerebral ischaemia in the gerbil. J Cereb Blood Flow Metab. 1982 Sep;2(3):299–306. doi: 10.1038/jcbfm.1982.31. [DOI] [PubMed] [Google Scholar]