Abstract
Chemotherapeutic agents are known to cause multiple toxicities such as myelotoxicity, nephrotoxicity and ototoxicity. A prospective study was carried out on 60 patients receiving Cisplatin based chemotherapy in a tertiary care centre. The effects of Cisplatin on auditory function were studied using metabolic, biochemical and audiological parameters. The auditory effects were correlated with the dose and duration of chemotherapy. The study concluded that a significant percentage (15%) of patients who were subjected to chemotherapy based on Cisplatin developed high frequency sensorineural hearing loss which was permanent and irreversible in nature.
Key Words: Chemotherapy, Cisplatin, Ototoxicity
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References
- 1.Primrose WJ. The principles of chemotherapy. In: Gleeson M, editor. Scott Brown’s Diseases of Ear, Nose and Throat. 6th Ed. London: Butterworth; 1997. pp. 1/22/7–1/22/10. [Google Scholar]
- 2.Scweitzer VG. Ototoxicity of chemotherapeutic agents. Otolaryngol Clin North Am. 1993;26:759–89. [PubMed] [Google Scholar]
- 3.McHaney VA, Thibadoux G, Hayes FA. Hearing loss in children receiving chemotherapy. J Paediatric. 1983;102:314–7. doi: 10.1016/S0022-3476(83)80551-4. [DOI] [PubMed] [Google Scholar]
- 4.Water GS, Ahmed M, Katsarkers A. Ototoxicity due to cisdiammine dichloroplatinum in treatment of ovarian cancer-Influence of dosage and schedule of administration. Ear Heart. 1991;12:91–102. doi: 10.1097/00003446-199104000-00003. [DOI] [PubMed] [Google Scholar]
- 5.Laurell G, Jungnelius V. High dose cisplatin treatment: Hearing loss and plasma concentration. Laryngoscope. 1990;100:724–34. doi: 10.1288/00005537-199007000-00008. [DOI] [PubMed] [Google Scholar]
- 6.Reddel RR, Kefford RF, Grant JM. Ototoxicity in patients receiving cisplatin; Importance of dose and method of administration. Cancer Treat Rep. 1982;66:19–23. [PubMed] [Google Scholar]
- 7.Kopelman J, Kramer BM, Budnick AS, Roy BS, Kramer BS. Ototoxicity of high dose cisplatin by bolus administration in patients with advanced cancer and normal hearing. Laryngoscope. 1998;98:858–64. doi: 10.1288/00005537-198808000-00014. [DOI] [PubMed] [Google Scholar]
- 8.Piel I, Meyer D, Perlia CP. Effects of Cisdiammine dichloroplatinum on hearing in man. Cancer Chemotherap Rep. 1974;58:871–5. [PubMed] [Google Scholar]