Skip to main content
The Journal of Headache and Pain logoLink to The Journal of Headache and Pain
. 2009 Jan 31;10(2):101–103. doi: 10.1007/s10194-009-0098-2

Smoking as a precipitating factor for migraine: a survey in medical students

L López-Mesonero 1, S Márquez 1, P Parra 1, G Gámez-Leyva 2, P Muñoz 3, Julio Pascual 4,
PMCID: PMC3451643  PMID: 19184325

Abstract

Our aim was to analyse the relationship between migraine and smoking in medical students. Medical students who had already received teaching on migraine were asked to answer an ad hoc questionnaire. A total of 361 students filled in the questionnaire: 245 (68%) were women. International Headache Society criteria were fulfilled by 58 (prevalence of migraine 16%) students. A total of 74 (20%) were current smokers: 21 males (18% of men were smokers) and 53 females (22% smokers). Within those 58 students with migraine, 17 (29%) smoke: only 2 were males (14% of males with migraine smoked) while the remaining 15 were females (34% of women with migraine smoked). Within those 17 students who were smokers and migraineurs, 12 (71%) thought that smoking worsens migraine and 10 (59%) that smoking precipitates attacks. The minimum number of cigarettes which subjectively precipitates attacks was 5. Migraine prevalence in the 20s in Spain is 16%. Our data obtained in medical students suggest that smoking can be a precipitating factor for migraine attacks, as the prevalence of active smoking is one-third higher in migraineurs and as there seems to be a relationship between the number of cigarettes and the development of migraine attacks.

Keywords: Migraine, Smoking

Full Text

The Full Text of this article is available as a PDF (173.1 KB).

Acknowledgments

Conflict of interest

None.

References

  • 1.Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J. Epidemiology of headache in Europe. Eur J Neurol. 2006;13:333–345. doi: 10.1111/j.1468-1331.2006.01184.x. [DOI] [PubMed] [Google Scholar]
  • 2.Headache Classification Committee of the International Headache Society (2004). The International Classification of Headache Disorders. 2nd edn. Cephalalgia 24(Suppl 1):1–160 [DOI] [PubMed]
  • 3.Laínez MJA, Vioque J, Hernández-Aguado I, Titus F. Prevalence of migraine in Spain. An assessment of the questionnaire’s validity by clinical interview. In: Olesen J, editor. Frontiers in headache research: headache classification and epidemiology. New York: Raven Press; 1994. pp. 221–225. [Google Scholar]
  • 4.Celik Y, Ekuklu G, Tokuc B, Utku U. Migraine prevalence and some related factors in Turkey. Headache. 2005;45:32–36. doi: 10.1111/j.1526-4610.2005.05007.x. [DOI] [PubMed] [Google Scholar]
  • 5.Vlajinac H, Sipetic S, Dzoljic E, Maksimovic J, Kostic V. Some lifestyle habits of female Belgrade university students with migraine and non-migraine headache. J Headache Pain. 2003;4:67–71. doi: 10.1007/s10194-003-0033-x. [DOI] [Google Scholar]
  • 6.Hannerz J. Symptoms and diseases and smoking habits in female episodic cluster headache and migraine patients. Cephalalgia. 1997;17:499–500. doi: 10.1046/j.1468-2982.1997.1704499.x. [DOI] [PubMed] [Google Scholar]
  • 7.Kudrow L. Cluster headache: mechanisms and management. New York: Oxford University Press; 1980. [Google Scholar]
  • 8.Manzoni GC, Bono G, Lanfranchi M, Micieli G, Martucci N, Nappi G. Lithium carbonate on cluster headache: assessment of its short- and long-term therapeutic efficacy. Cephalalgia. 1983;3:109–114. doi: 10.1046/j.1468-2982.1983.0302109.x. [DOI] [PubMed] [Google Scholar]
  • 9.Sjaastad O. Cluster headache syndrome. London: Saunders; 1992. [Google Scholar]
  • 10.Chen TC, Leviton A, Edelstein S, Ellenberg JH. Migraine and other diseases in women of reproductive age. The influence of smoking on observed association. Arch Neurol. 1987;44:1024–1028. doi: 10.1001/archneur.1987.00520220030011. [DOI] [PubMed] [Google Scholar]
  • 11.Rasmussen BK. Migraine and tension-type headache in a general population: precipitating factors, female hormones, sleep patterns and relation lifestyle. Pain. 1993;53:65–72. doi: 10.1016/0304-3959(93)90057-V. [DOI] [PubMed] [Google Scholar]
  • 12.Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y, et al. Population-based door-to-door survey of migraine in Japan: the Daisen study. Headache. 2004;44:8–19. doi: 10.1111/j.1526-4610.2004.04004.x. [DOI] [PubMed] [Google Scholar]
  • 13.Spierings ELH, Ranke AH, Honkoop PC. Precipitating and aggravating factors of migraine versus tension-type headache. Headache. 2001;41:554–558. doi: 10.1046/j.1526-4610.2001.041006554.x. [DOI] [PubMed] [Google Scholar]
  • 14.Payne TJ, Stetson B, Stevens VM, Johnson CA, Penzien DB, Dorsten B. The impact of cigarette smoking on headache activity in headache patients. Headache. 1991;31:329–332. doi: 10.1111/j.1526-4610.1991.hed3105329.x. [DOI] [PubMed] [Google Scholar]
  • 15.Mannix LK, Frame JR, Solomon GD. Alcohol, smoking, and caffeine use among headache patients. Headache. 1997;37:572–576. doi: 10.1046/j.1526-4610.1997.3709572.x. [DOI] [PubMed] [Google Scholar]
  • 16.Volans GN, Castleden CM. The relationship between smoking and migraine. Postgrad Med J. 1976;52:80–82. doi: 10.1136/pgmj.52.604.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Littlewood JT, Glover V, Sandler M, Petty R, Peatfield R, Clifford-Rose F. Migraine and cluster headache: links between platelet monoamine oxidase activity, smoking and personality. Headache. 1984;24:30–34. doi: 10.1111/j.1526-4610.1984.hed2401030.x. [DOI] [PubMed] [Google Scholar]
  • 18.Lassen LH, Ashina M, Christiansen I, Olesen J. Nitric oxide synthase inhibition in migraine. Lancet. 1997;349:401–402. doi: 10.1016/S0140-6736(97)80021-9. [DOI] [PubMed] [Google Scholar]
  • 19.Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor R, et al. Inhibition of monoamine oxidase B in the brains of smokers. Nature. 1996;379:733–738. doi: 10.1038/379733a0. [DOI] [PubMed] [Google Scholar]
  • 20.Fergusson DM, Goodwin RD, Horwood LJ. Major depression and cigarette smoking: results of a 21-year longitudinal study. Psychol Med. 2003;33:1357–1367. doi: 10.1017/S0033291703008596. [DOI] [PubMed] [Google Scholar]
  • 21.Zanchin G, Dainese F, Mainardi F, Mampreso E, Perin C, Maggioni F. Osmophobia in primary headaches. J Headache Pain. 2005;6:213–215. doi: 10.1007/s10194-005-0188-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Zanchin G, Dainese F, Trucco M, Mainardi F, Mampreso E, Maggioni F. Osmophobia in migraine and tension-type headache and its clinical features in patients with migraine. Cephalalgia. 2007;27:1061–1068. doi: 10.1111/j.1468-2982.2007.01421.x. [DOI] [PubMed] [Google Scholar]
  • 23.Quintela E, Castillo J, Muñoz P, Pascual J. Premonitory and resolution symptoms in migraine: a prospective study in 100 unselected patients. Cephalalgia. 2006;26:1051–1060. doi: 10.1111/j.1468-2982.2006.01157.x. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Headache and Pain are provided here courtesy of BMC

RESOURCES