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. 1984 May;81(9):2836–2839. doi: 10.1073/pnas.81.9.2836

Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

D Drayna, K Davies, D Hartley, J L Mandel, G Camerino, R Williamson, R White
PMCID: PMC345165  PMID: 6326147

Abstract

Using a human X chromosome-specific DNA library, we have found arbitrary single-copy DNA sequences that reveal useful restriction fragment length polymorphisms. The inheritance of these and other available polymorphic DNA markers has been studied in a series of unrelated three-generation families with large sibships. These families reveal parental phase and allow determination of recombination frequencies by counting recombinant and nonrecombinant chromosomes. The resulting genetic map indicates that the minimal distance from Xp22 to Xqter is 215 recombination units. The spacing of the marker loci is such that the majority of the loci on the X chromosome, including disease loci, will lie within 20 centimorgans of at least one of these loci.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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