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. 1984 May;81(9):2864–2867. doi: 10.1073/pnas.81.9.2864

Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.

G T Nepom, K A Nelson, S L Holbeck, I Hellström, K E Hellström
PMCID: PMC345172  PMID: 6609369

Abstract

Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8.2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells.

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Selected References

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