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. 1984 May;81(9):2912–2916. doi: 10.1073/pnas.81.9.2912

The structure of bovine brain myelin proteolipid and its organization in myelin.

R A Laursen, M Samiullah, M B Lees
PMCID: PMC345183  PMID: 6201866

Abstract

A model, based on amino acid sequence data, is proposed for the organization of the myelin proteolipid in myelin membrane. The model has three distinctive features: three trans-membrane segments that traverse the lipid bilayer, two cis-membrane domains that enter and exit the same side of the membrane, and a highly charged segment resembling myelin basic protein on the cytoplasmic side of the membrane. It is proposed that the cis-membrane domain(s) can promote the formation and stabilization of the multilamellar myelin structure by hydrophobic interaction with the apposite bilayer across the extracellular space.

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Selected References

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