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. 2010 Jun 2;11(5):405–407. doi: 10.1007/s10194-010-0225-0

Are Cox-2 drugs the second line option in indomethacin responsive headaches?

Jesús Porta-Etessam 1,2,✉, Marialuz Cuadrado 1,2, Octavio Rodríguez-Gómez 2, Sara García-Ptacek 2, Cristina Valencia 2
PMCID: PMC3452276  PMID: 20517705

Abstract

Paroxysmal hemicrania and hemicrania continua are both indomethacin-responsive headaches. Although indomethacin use to be well tolerated, some patients developed gastrointestinal side effects. We report four cases of hemicrania continua and a patient suffering chronic paroxysmal hemicrania completely responsive to celecoxib. In our experience celecoxib is a good option treatment for patients suffering from hemicrania continua or chronic paroxysmal hemicranea that presents indomethacin adverse effects.

Keywords: Hemicrania continua, Chronic paroxysmal hemicrania, COX-2, Celecoxib

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Conflict of interest

None.

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