Abstract
Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined. This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864, P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid and improves Hamilton Rating Scale for Depression score in major depressive disorder.
Key Words: Uric acid, Citalopram, Fluoxetine, Hamilton Rating Scale for Depression score, Major depression, Selective Serotonin Re-Uptake Inhibitors
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References
- 1.MENTAL HEALTH Regional Committee for the Eastern Mediterranean Forty-eighth Session Riyadh, Saudi Arabia, 30 September — 3 October 2001 Accessed from: http://www.emro.who.int/RC48/RC48INFDOC1.htm Accessed on: 23rd OCT 2005.
- 2.Khanzode S.D., Dakhale G.N., Khanzode S.S., Saoji A., Palsodkar R. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Report. 2003;8(6):365–370. doi: 10.1179/135100003225003393. [DOI] [PubMed] [Google Scholar]
- 3.Bilici M., Efe H., Koroglu M.A., Uydu H.A., Bekaroglu M., Deger O. Antioxidative enzyme activities and lipid peroxidation in major depression: alteration by antidepressant treatments. J Affect Dis. 2001;64:43–51. doi: 10.1016/S0165-0327(00)00199-3. [DOI] [PubMed] [Google Scholar]
- 4.Sapolsky R.M. The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol Psychiatry. 2000;48:755–765. doi: 10.1016/S0006-3223(00)00971-9. [DOI] [PubMed] [Google Scholar]
- 5.Ozcan M.E., Gulec M., Ozerol E., Polat R., Akyol O. Antioxidant enzyme activities and oxidative stress in affective disorders. Int Clin Psychopharmacol. 2004;19(2):89–95. doi: 10.1097/00004850-200403000-00006. [DOI] [PubMed] [Google Scholar]
- 6.Sen C.K. Oxygen toxicity and antioxidants: state of the art. Ind J Physiol Pharmacol. 1995;39(3):177–196. [PubMed] [Google Scholar]
- 7.Singh R.P., Sharad S., Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: relevance of dietary antioxidants. JIACM. 2004;5(3):218–225. [Google Scholar]
- 8.Kane P. Understanding the biochemical and biobehavioral nexus of depression. Nutritonal Research 1997; Explore issue, vol. 8(1). Accessed from: http://www.explorepub.com/articles/nutrition2.html Accessed on 23rd Jan 2005.
- 9.Maes M., Wauters A., Neels H., Scharpe S., Gastel A.V., D’Hondt P., et al. Total serum protein and serum protein fractions in depression: relationship to depressive symptoms and glucocorticoid activity. J Affect Dis. 1995;34:61–69. doi: 10.1016/0165-0327(94)00106-J. [DOI] [PubMed] [Google Scholar]
- 10.Yanik E., Erel O., Kati M. The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatrica. 2004;16:200–203. doi: 10.1111/j.0924-2708.2004.00090.x. [DOI] [PubMed] [Google Scholar]
- 11.Koo J.R., Yoon J.Y., Joo M.H., Lee H.S., Oh J.E., Kim S.G., et al. Treatment of depression and effect of antidepressant on nutritional status in chronic hemodialysis patients. Am J Med Sci. 2005;329(1):1–5. doi: 10.1097/00000441-200501000-00001. [DOI] [PubMed] [Google Scholar]
- 12.Catalano M.C., Catalano G., Kanfer S.N., Toner L.C., Stock S.L., Tayler W.D. The effect of sertraline on routine blood chemistry values. Clin Neuropharmacol. 2000;23(5):267–270. doi: 10.1097/00002826-200009000-00005. [DOI] [PubMed] [Google Scholar]
- 13.Stahl S.M. Essential psychopharmacology neuroscientific basis and practical application. New Delhi: Foundation books (Cambridge University Presss); 1998. Antidepressants and mood stabilizers; pp. 131–166. [Google Scholar]
- 14.Yao J.K., Reddy R., Kammen D.P. Reduced level of plasma antioxidant uric acid in schizophrenia. Psychiatry Res. 1998;80:29–39. doi: 10.1016/S0165-1781(98)00051-1. [DOI] [PubMed] [Google Scholar]
- 15.Kharb S., Singh V. Total free radical trapping antioxidant potential in normal pregnancy. J Obstet Gynecol Ind. 2004;54(3):249–250. [Google Scholar]
- 16.Rodionov R.N. Urate as an endogenous antioxidant. Free Radicals in Biology and Medicine. 2003;77(222):1–11. [Google Scholar]
- 17.Yao J.K., Leonard S., Reddy R.D. Increased nitric oxide radicals in postmortem brain from patients with schizophrenia. Schizophr Bull. 2004;30(4):923–934. doi: 10.1093/oxfordjournals.schbul.a007142. [DOI] [PubMed] [Google Scholar]
- 18.Teng R.J., Ye Y.Z., Parks D.A., Beckman J.S. Urate produced during hypoxia protects heart proteins from peroxynitrite mediated protein nitration. Free Radic Biol Med. 2002;33(9):1243–1249. doi: 10.1016/S0891-5849(02)01020-1. [DOI] [PubMed] [Google Scholar]
- 19.Anderson R.F., Harris T.A. Dopamine and uric acid acts as antioxidants in the repair of DNA radicals: implications in Parkinson’s disease. Free Radic Res. 2003;37(10):1131–1136. doi: 10.1080/10715760310001604134. [DOI] [PubMed] [Google Scholar]
- 20.Li X.M., Chlan F.J., Juorio A.V., Bennett V.L., Shrikhande S., Bowen R.O. Antidepressants up regulate m-RNA levels of the neuroprotetcive enzyme, superoxide dismutase. J Psychiatr Neurosci. 2000;25:43–47. [PMC free article] [PubMed] [Google Scholar]