Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Jun;81(12):3838–3842. doi: 10.1073/pnas.81.12.3838

Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.

J Wieslander, J F Barr, R J Butkowski, S J Edwards, P Bygren, D Heinegård, B G Hudson
PMCID: PMC345316  PMID: 6328527

Abstract

The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.

Full text

PDF
3838

Images in this article

3839Image
on p.3839
3840Image
on p.3840
3840Image
on p.3840
3841Image
on p.3841

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Crouch E., Bornstein P. Characterization of a type IV procollagen synthesized by human amniotic fluid cells in culture. J Biol Chem. 1979 May 25;254(10):4197–4204. [PubMed] [Google Scholar]
  2. Dean D. C., Barr J. F., Freytag J. W., Hudson B. G. Isolation of type IV procollagen-like polypeptides from glomerular basement membrane. Characterization of pro-alpha 1(IV). J Biol Chem. 1983 Jan 10;258(1):590–596. [PubMed] [Google Scholar]
  3. Fessler L. I., Fessler J. H. Identification of the carboxyl peptides of mouse procollagen IV and its implications for the assembly and structure of basement membrane procollagen. J Biol Chem. 1982 Aug 25;257(16):9804–9810. [PubMed] [Google Scholar]
  4. Fish A. J., Carmody K. M., Michael A. F. Spatial orientation and distribution of antigens within human glomerular basement membrane. J Lab Clin Med. 1979 Sep;94(3):447–457. [PubMed] [Google Scholar]
  5. Freytag J. W., Ohno M., Hudson B. G. Bovine renal glomerular basement membrane. Assessment of proteolysis during isolation. Biochem Biophys Res Commun. 1976 Oct 4;72(3):796–802. doi: 10.1016/s0006-291x(76)80203-3. [DOI] [PubMed] [Google Scholar]
  6. Kleinman H. K., McGarvey M. L., Liotta L. A., Robey P. G., Tryggvason K., Martin G. R. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry. 1982 Nov 23;21(24):6188–6193. doi: 10.1021/bi00267a025. [DOI] [PubMed] [Google Scholar]
  7. Lee-Own V., Anderson J. C. The preparation of a bacterial collagenase containing negligible non-specific protease activity. Prep Biochem. 1975;5(3):229–245. doi: 10.1080/00327487508061574. [DOI] [PubMed] [Google Scholar]
  8. Lerner R. A., Glassock R. J., Dixon F. J. The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med. 1967 Dec 1;126(6):989–1004. doi: 10.1084/jem.126.6.989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mahieu P., Lambert P. H., Miescher P. A. Detection of anti-glomerular basement membrane antibodies by radioimmunological technique. Clinical application in human nephropathies. J Clin Invest. 1974 Jul;54(1):128–137. doi: 10.1172/JCI107734. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Marquardt H., Wilson C. B., Dixon F. J. Isolation and immunological characterization of human glomerular basement membrane antigens. Kidney Int. 1973 Feb;3(2):57–65. doi: 10.1038/ki.1973.12. [DOI] [PubMed] [Google Scholar]
  11. Martinez-Hernandez A., Amenta P. S. The basement membrane in pathology. Lab Invest. 1983 Jun;48(6):656–677. [PubMed] [Google Scholar]
  12. McIntosh R. M., Copack P., Chernack W. B., Griswold W. R., Weil R., 3rd, Koss M. N. The human choroid plexus and autoimmune nephritis. Arch Pathol. 1975 Jan;99(1):48–50. [PubMed] [Google Scholar]
  13. McPhaul J. J., Jr, Dixon F. J. Characterization of human anti-glomerular basement membrane antibodies eluted from glomerulonephritic kidneys. J Clin Invest. 1970 Feb;49(2):308–317. doi: 10.1172/JCI106240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Oberbäumer I., Wiedemann H., Timpl R., Kühn K. Shape and assembly of type IV procollagen obtained from cell culture. EMBO J. 1982;1(7):805–810. doi: 10.1002/j.1460-2075.1982.tb01251.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Peters D. K., Rees A. J., Lockwood C. M., Pusey C. D. Treatment and prognosis in antibasement membrane antibody-mediated nephritis. Transplant Proc. 1982 Sep;14(3):513–521. [PubMed] [Google Scholar]
  16. Schuppan D., Timpl R., Glanville R. W. Discontinuities in the triple helical sequence Gly-X-Y of basement membrane (type IV) collagen. FEBS Lett. 1980 Jun 30;115(2):297–300. doi: 10.1016/0014-5793(80)81191-4. [DOI] [PubMed] [Google Scholar]
  17. Tanzer M. L., Kefalides N. A. Collagen crosslinks: occurrence in basement membrane collagens. Biochem Biophys Res Commun. 1973 Apr 2;51(3):775–780. doi: 10.1016/0006-291x(73)91382-x. [DOI] [PubMed] [Google Scholar]
  18. Timpl R., Martin G. R., Bruckner P., Wick G., Wiedemann H. Nature of the collagenous protein in a tumor basement membrane. Eur J Biochem. 1978 Mar;84(1):43–52. doi: 10.1111/j.1432-1033.1978.tb12139.x. [DOI] [PubMed] [Google Scholar]
  19. Timpl R., Wiedemann H., van Delden V., Furthmayr H., Kühn K. A network model for the organization of type IV collagen molecules in basement membranes. Eur J Biochem. 1981 Nov;120(2):203–211. doi: 10.1111/j.1432-1033.1981.tb05690.x. [DOI] [PubMed] [Google Scholar]
  20. West T. W., Fox J. W., Jodlowski M., Freytag J. W., Hudson B. G. Bovine glomerular basement membrane. Properties of the collagenous domain. J Biol Chem. 1980 Nov 10;255(21):10451–10459. [PubMed] [Google Scholar]
  21. Wieslander J., Bygren P., Heinegård D. Antiglomerular basement membrane antibody: antibody specificity in different forms of glomerulonephritis. Kidney Int. 1983 Jun;23(6):855–861. doi: 10.1038/ki.1983.106. [DOI] [PubMed] [Google Scholar]
  22. Wieslander J., Bygren P., Heinegård D. Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. Proc Natl Acad Sci U S A. 1984 Mar;81(5):1544–1548. doi: 10.1073/pnas.81.5.1544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wilson C. B., Holdsworth S. R., Neale T. J. Anti-basement membrane antibodies in immunologic renal disease. Aust N Z J Med. 1981;11(Suppl 1):94–100. [PubMed] [Google Scholar]
  24. Yaar M., Foidart J. M., Brown K. S., Rennard S. I., Martin G. R., Liotta L. The Goodpasture-like syndrome in mice induced by intravenous injections of anti-type IV collagen and anti-laminin antibody. Am J Pathol. 1982 Apr;107(1):79–91. [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES