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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Jun;81(12):3843–3845. doi: 10.1073/pnas.81.12.3843

A monoclonal anti-DNA antibody also binds to cell-surface protein(s).

L Jacob, F Tron, J F Bach, D Louvard
PMCID: PMC345317  PMID: 6374668

Abstract

A murine monoclonal anti-DNA antibody ( PME77 ) has been found to bind tightly to the plasma membrane of Raji cells. We show here that this monoclonal anti-DNA antibody reacts in a radioimmunoassay with the cell surface of a variety of mammalian cell types and that the antigenic determinant recognized by the monoclonal anti-DNA antibody at the surface of Raji cells is resistant to DNase. It belongs to polypeptides removed from the cell surface by a mild proteinase K treatment.

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Selected References

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