Skip to main content
NCBI home page
Journal of Digital Imaging logoLink to Journal of Digital Imaging
. 2000 May;13(Suppl 1):39–42. doi: 10.1007/BF03167621

Shape analysis of hippocampal surface structure in patients with unilateral mesial temporal sclerosis

R Edward Hogan 1,2,✉, Richard D Bucholz 1,2, Indrajit Choudhuri 1,2, Kevin E Mark 1,2, Chris S Butler 1,2, Sarang Joshi 1,2
PMCID: PMC3453288  PMID: 10847359

Abstract

Structural hippocampal magnetic resonance (MR) imaging-based analysis is helpful in the diagnosis and treatment of mesial temporal epileptic seizures. Computational anatomic techniques provide a framework for objective assessment of three-dimensional hippocampal structure. We applied a previously validated technique of deformation-based hippocampal segmentations in 20 subjects with documented unilateral mesial temporal sclerosis (MTS) and temporal lobe epilepsy. Using composite images, we then measured shape differences between the epileptogenic, smaller hippocampus, and contralateral hippocampus. Final shape differences were projected on the contralateral “normal” side. We calculated results for the left MTS group (10 patients) and right MTS group (10 patients) separately. Both groups showed similar regions of maximal inward deformation in the affected hippocampus, which were the medical and lateral aspect of the head, and posterior aspect of the tail. These results suggest that there are specific three-dimensional patterns of volume loss in patients with mesial temporal epilepsy.

Full Text

The Full Text of this article is available as a PDF (914.6 KB).

References

  • 1.Lencz T, McCarthy G, Bronen RA, et al. Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function. Ann Neurol. 1992;31:629–637. doi: 10.1002/ana.410310610. [DOI] [PubMed] [Google Scholar]
  • 2.Cascino GD. Clinical correlations with hippocampal atrophy. Magn Reson Imaging. 1995;13:1133–1136. doi: 10.1016/0730-725X(95)02023-M. [DOI] [PubMed] [Google Scholar]
  • 3.Jack CR, Sharbrough FW, Cascino GD, et al. Magnetic resonance image-based hippocampal volumetry: Correlation with outcome after temporal lobectomy. Ann Neurol. 1992;31:138–146. doi: 10.1002/ana.410310204. [DOI] [PubMed] [Google Scholar]
  • 4.Cascino GD. Clinical evaluation and noninvasive electroencephalography. Preoperative evaluation. Neuroimaging Clin North Am. 1995;5:547–558. [PubMed] [Google Scholar]
  • 5.Kim JH, Tien RD, Felsberg GJ, et al. Fast spin-echo MR in hippocampal sclerosis: Correlation with pathology and surgery. AJNR. 1995;16:627–636. [PMC free article] [PubMed] [Google Scholar]
  • 6.Arruda F, Cendes F, Andermann F, et al. Mesial atrophy and outcome after amygdalohippocampectomy or temporal lobe removal. Ann Neurol. 1996;40:446–450. doi: 10.1002/ana.410400314. [DOI] [PubMed] [Google Scholar]
  • 7.Holmes MD, Dodrill CB, Ojemann GA, et al. Outcome following surgery in patients with bitemporal interictal epileptiform patterns. Neurology. 1997;48:1037–1040. doi: 10.1212/wnl.48.4.1037. [DOI] [PubMed] [Google Scholar]
  • 8.Watson C, Jack CR, Cendes F. Volumetric magnetic resonance imaging. Clinical applications and contributions to the understanding of temporal lobe epilepsy. Arch Neurol. 1997;54:1521–1531. doi: 10.1001/archneur.1997.00550240071015. [DOI] [PubMed] [Google Scholar]
  • 9.Grenander U. General Pattern Theory. London, UK: Oxford University Press; 1993. [Google Scholar]
  • 10.Miller MI, Joshi SC, Christensen GE. Large deformation fluid diffeomorphisms for landmark and image matching. In: Toga AW, editor. Brain Warping. San Diego, CA: Academic Press; 1999. pp. 115–131. [Google Scholar]
  • 11.Christensen GE, Rabbitt RD, Miller MI, Runolfsson T. A deformable neuroanatomy textbook based on viscous fluid mechanics. In: Prince J, editor. Proceedings of the 27th Annual Conference on Information Sciences and Systems. Baltimore, MD: The Johns Hopkins University; 1993. pp. 211–216. [Google Scholar]
  • 12.Miller MI, Christensen GE, Amit Y, et al. Mathematical textbook for deformable neuroanatomies. Proc Natl Acad Sci USA. 1993;90:11944–11948. doi: 10.1073/pnas.90.24.11944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Miller MI, Grenander U. Computational anatomy: an emerging discipline. Q Appl Mathematics. 1998;5:617–694. [Google Scholar]
  • 14.Haller JW, Banerjee A, Christensen GE, et al. Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas. Radiology. 1997;202:504–510. doi: 10.1148/radiology.202.2.9015081. [DOI] [PubMed] [Google Scholar]
  • 15.Hogan RE, Mark KE, Wang L, et al. MR imaging deformation-based segmentation of the hippocampus in patients with mesial temporal sclerosis and temporal lobe epilepsy. Epilepsia. 1999;40:192–192. doi: 10.1007/BF03167670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Talairach J, Tournoux P. Coplanar Sterotactic Atlas of the Human Brain. New York, NY: Thieme; 1988. [Google Scholar]
  • 17.Joshi S. Large deformation diffeomorphisms and gaussian random fields for statistical characterization of brain submanifolds. Saint Louis, MO: Washington University; 1997. [Google Scholar]
  • 18.Joshi SC, Miller MI, Christensen GE, et al: Hierarchical brain mapping via a generalized Dirichlet solution for mapping brain manifolds, in Proceedings of the SPIE’s 1995 International Symposium on Optical Science, Engineering, and Instrumentation: Vision Geometry IV, vol 2573. San Diego, CA, 1995, pp 278–289
  • 19.Christensen GE, Rabbitt RD, Miller MI. (3D) Brain mapping using a deformable neuroanatomy. Phys Med Biol. 1994;39:609–618. doi: 10.1088/0031-9155/39/3/022. [DOI] [PubMed] [Google Scholar]
  • 20.Christensen GE, Rabbitt RD, Miller MI, DiPaela R, et al. Topological properties of smooth anatomic maps. In: Bizals Y, Barillot C, et al., editors. Information Processing in Medical Imaging. Norwell, MA: Kluwer Academic; 1995. pp. 101–112. [Google Scholar]
  • 21.Christensen GE, Joshi SC, Miller MI. Volumetric transformation of brain anatomy. IEEE Trans Med Imaging. 1997;16:864–877. doi: 10.1109/42.650882. [DOI] [PubMed] [Google Scholar]
  • 22.Jack CR, Petersen RC, Xu Y, et al. Rate of medial temporal lobe atrophy in typical aging and Alzheimer’s disease. Neurology. 1998;51:993–999. doi: 10.1212/wnl.51.4.993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Frisoni GB, Laakso MP, Beltramello A, et al. Hippocambal and entorinhal cortex atrophy in frontotemporal dementia and Alzheimer’s disease. Neurology. 1999;52:91–100. doi: 10.1212/wnl.52.1.91. [DOI] [PubMed] [Google Scholar]
  • 24.Press GA, Amaral DG, Squire LR. Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging. Nature. 1989;341:54–57. doi: 10.1038/341054a0. [DOI] [PubMed] [Google Scholar]
  • 25.Csernansky JG, Joshi S, Wang L, et al. Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci USA. 1998;95:11406–11411. doi: 10.1073/pnas.95.19.11406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Shenton ME, Kikinis R, Jolesz FA, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. N Engl J Med. 1992;327:604–612. doi: 10.1056/NEJM199208273270905. [DOI] [PubMed] [Google Scholar]
  • 27.Joshi S, Miller MI, Grenander U. On the geometry and shape of brain sub-manifolds. Int J Pattern Recogn Artif Intell. 1997;11:8–8. doi: 10.1142/S0218001497000615. [DOI] [Google Scholar]
  • 28.Cook MJ, Fish DR, Shorvon SD, et al. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain. 1992;115:1001–1015. doi: 10.1093/brain/115.4.1001. [DOI] [PubMed] [Google Scholar]
  • 29.Bronen RA, Fulbright RK, Kim JH, et al. Regional distribution of MR findings in hippocampal sclerosis. AJNR. 1995;16:1193–1200. [PMC free article] [PubMed] [Google Scholar]
  • 30.Oppenheim C, Dormont D, Biondi A, et al. Loss of digitations of the hippocampal head on high-resolution fast spin-echo MR: A sign of mesial temporal sclerosis. AJNR. 1998;19:457–463. [PMC free article] [PubMed] [Google Scholar]
  • 31.Jackson GD, Kuzniecky RI, Cascino GD. Hippocampal sclerosis without detectable hippocampal atrophy. Neurology. 1994;44:42–46. doi: 10.1212/wnl.44.1.42. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Digital Imaging are provided here courtesy of Springer

RESOURCES