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Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 2000 Aug;15(1):36–39. doi: 10.1007/BF02873545

Serum ionised calcium in birth asphyxia

B K Jain 1,, Daljit Singh 1, Harmesh Singh 1, A P S Narang 2, Praveen C Sobti 1, Ajay Gupta 1
PMCID: PMC3453544  PMID: 23105235

Abstract

Serum total and ionised calcium levels were measured at birth and at 48 hours in 25 term neonates with birth asphyxia (one minute APGAR score of 6 or less) and in 25 normal term neonates (one minute APGAR score of 7 or more). Infants were categorised into two groups TAGA (term appropriate for gestational age) and TSGA (term small for gestational age). Asphyxiated infants had significantly lower serum total and ionised calcium values at birth as well as at 48 hours. Abnormal clinical features were observed in 48% of asphyxiated infants. Low ionised calcium was detected in symptomatic babies, who had otherwise normal total calcium values. Due to hyocalcemia especially ionised calcium in asphyxiated infants and high frequency of functional derangement associated with this hypocalcemioa, serial monitoring of serum isonised calcium levels is necessary.

Key Words: Birth asphyxia, Serum ionised calcium

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References

  • 1.Brown D.M. Proposal for a new method of evaluation of the newborn infant. Anesth. Anagg. 1953;32:260–266. [PubMed] [Google Scholar]
  • 2.David L, Anast C. Calcium metabolism in newborn infants. J. Clin. Invest. 1974;54:287–290. doi: 10.1172/JCI107764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Tsang R.C., Danovan E.F., Steinchen J.J. Calcium physiology in the neonates. Pediatric Clinic North Am. 1976;23:611–726. doi: 10.1016/s0031-3955(16)33348-x. [DOI] [PubMed] [Google Scholar]
  • 4.Tsang R.C., Light I.J., Sutherland J.M., Klenman L.I. Possible pathogenitic factors in neonatal hypocalcemia of prematurity. Journal of Pediatrics. 1973;82:423–429. doi: 10.1016/S0022-3476(73)80115-5. [DOI] [PubMed] [Google Scholar]
  • 5.Jajoo D., Kumar A., Shankar R., Bhargava V. Effects of birth asphyxia on serum calcium levels in neonates. Indian Pediatrics. 1995;62:455–459. doi: 10.1007/BF02755067. [DOI] [PubMed] [Google Scholar]
  • 6.Tsang R.C., Chen I., Hayes W. Neonatal hypocalcemia in infants with birth asphyxia. Journal of Pediatrics. 1974;84:428–433. doi: 10.1016/S0022-3476(74)80733-X. [DOI] [PubMed] [Google Scholar]
  • 7.Apgar V.A. Proposal for a new method of evaluation of the newborn infant. Anesth. Analg. 1953;32:260–266. doi: 10.1213/00000539-195301000-00041. [DOI] [PubMed] [Google Scholar]
  • 8.Loughead L.J., Minouni F., Tsang R.C. Serum ionised calcium concentrations in normal neonates. AmerJ Dis.Child. 1988;142:516–518. doi: 10.1001/archpedi.1988.02150050054030. [DOI] [PubMed] [Google Scholar]
  • 9.Tsang R.C., Giger M.Ch. W., Brown D.R. Studies in calcium metabolism in infants with intrauterine growth retardation. Journal of Pediatrics. 1975;86:936–941. doi: 10.1016/S0022-3476(75)80232-0. [DOI] [PubMed] [Google Scholar]
  • 10.Payne W.W., Acharya P.C. Effect of abnormal, birth on blood chemistry during the first 48 hours of life. Arch. Dis. Child. 1965;40:436–441. doi: 10.1136/adc.40.212.436. [DOI] [PMC free article] [PubMed] [Google Scholar]

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