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Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 1998 Jul;13(2):119–122. doi: 10.1007/BF02867873

Effect of short term vitamin E supplementation on lipid peroxidation in acute myocardial infarction

A P Jain 1,, A Mohan 1, O P Gupta 1, U N Jajoo 1, S P Kalantri 1, L M Srivastava 2
PMCID: PMC3453572  PMID: 23105192

Abstract

In view of sufficient body of evidence to substantiate the role of free radical mediated oxidative injury in myocardial infarction (M.I.), the utility of exogenous supplementation with antioxidant substance, vitamin E was studied. Forty patients of acute myocardial infarction were divided into two equal groups, one who received vitamin E and the other who did not. Plasma MDA levels showed a reduction in patients of M.I. who received vitamin E as well as in those who did not, however, the decrease was significantly more in the vitamin E treated subgroup.

Key Words: Vitamin E, Lipid peroxidation, Myocardial infarction

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References

  • 1.Recommended Dietary Allowances. 9th ed. Washington, DC. U.S.A.: National Academy Press; 1980. [Google Scholar]
  • 2.Machlin L.N., Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. Fed. Amer. Soc. Exp. Biol. J. 1987;1:441–445. [PubMed] [Google Scholar]
  • 3.Ingold K.U., Webb A.C., Witter D. Vitamin E remains the major lipid soluble chain breaking antioxidant in human plasma even in individuals, suffering severe vitamin E deficiency. Arch. Biochem. Biophys. 1987;259:224–225. doi: 10.1016/0003-9861(87)90489-9. [DOI] [PubMed] [Google Scholar]
  • 4.Bitman J., Weyant J., Wood D.L. Vitamin E, cholesterol and lipids during atherogenesis in rabbits. Lipids. 1976;11:449–461. doi: 10.1007/BF02532835. [DOI] [PubMed] [Google Scholar]
  • 5.Boogaerts M.A., Broeck J., Deckmyn H., Roelant C., Vermylen J., Verwilghen R.L. Protective effect of vitamin E of immune triggered granulocyte mediated endothelial injury. Thromb. Haemost. 1984;51:89–92. [PubMed] [Google Scholar]
  • 6.Stampfer M.J., Hennekens C.H., Manson J.E., Coldity G.A., Rosner B., Willett W.C. Vitamin-E consumption and the risk of coronary disease in women. New Engl. J. Med. 1993;328:1444–1449. doi: 10.1056/NEJM199305203282003. [DOI] [PubMed] [Google Scholar]
  • 7.Rimm E.B., Stampfer M.J., Asherio A., Giovannuci E., Coldity G.A., Willett W.C. Vitamin E consumption and the risk of coronary heart disease in men. New Engl. J. Med. 1993;328:1450–1456. doi: 10.1056/NEJM199305203282004. [DOI] [PubMed] [Google Scholar]
  • 8.Heinonen O.P., Alganes D. The alpha-tocopherol, beta-carotene cancer prevention study group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. New Engl. J. Med. 1994;330:1029–1035. doi: 10.1056/NEJM199404143301501. [DOI] [PubMed] [Google Scholar]
  • 9.Brown K.M., Morrice P.C., Duthie G.G. Vitamin E supplementation suppresses indexes of lipid peroxidation and platelet counts in blood of smokers and nonsmokers but plasma lipoprotein concentration remains unchanged. Amer. J. Clin. Nutr. 1994;60:383–387. doi: 10.1093/ajcn/60.3.383. [DOI] [PubMed] [Google Scholar]
  • 10.Singh R.G., Niaz M.A., Rastogi S.S. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3) Amer. J. Cardiol. 1996;77(4):232–236. doi: 10.1016/S0002-9149(97)89384-8. [DOI] [PubMed] [Google Scholar]
  • 11.Gillum R.F., Fostmann S.P., Prineas R.J. International diagnostic criteria for acute myocardial infarction and stroke. Amer. Heart J. 1984;87:577–583. doi: 10.1016/0002-8703(84)90558-1. [DOI] [PubMed] [Google Scholar]
  • 12.Rude R.E., Poole K., Muller J.E., Turi Z., Rutherfold J., Parker C., Roberts R., Raabe D.S., Gold H.K., Stone P.H. Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3697 patients. Amer. J Cardiol. 1983;52:936–942. doi: 10.1016/0002-9149(83)90508-8. [DOI] [PubMed] [Google Scholar]
  • 13.Satoh K. Serum lipid perioxide in cerebrovascular disorders determined by a new colorimetric method. Clin. Chim. Acta. 1978;90:37–43. doi: 10.1016/0009-8981(78)90081-5. [DOI] [PubMed] [Google Scholar]
  • 14.Jialal I., Fuller C.J., Huet B.A. The effect of alpha-tocopherol supplementation on LDL oxidation: a dose response study. Arterioscler. Thromb. Vasc. Biol. 1995;15:190–198. doi: 10.1161/01.atv.15.2.190. [DOI] [PubMed] [Google Scholar]
  • 15.Suzukawa M., Ishikawa T., Yoshida H., Nakamura H. Effect ofin vivo supplementation with low dose vitamin E or susceptibility of LDL and HDL to oxidative modification. J. Amer. Coll. Nutr. 1995;14:46–52. doi: 10.1080/07315724.1995.10718472. [DOI] [PubMed] [Google Scholar]
  • 16.Fuller C.J., Huet B.A., Jialal I. Effects of increasing doses of alpha tocopherol in providing protection of LDL from oxidation. Amer. J. Cardiol. 1998;81:231–233. doi: 10.1016/S0002-9149(97)00873-4. [DOI] [PubMed] [Google Scholar]

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