Abstract
Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl), low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased SOD need cardiovascular monitoring.
Key Words: Xanthelasma, apolipoprotein B, superoxide dismutase, malondialdehyde, coronary artery disease
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References
- 1.Bergman R. The pathogenesis and clinical significance of xanthelasma palpebrum. J. Amer. Acad. Dermatol. 1994;30:236–242. doi: 10.1016/s0190-9622(94)70023-0. [DOI] [PubMed] [Google Scholar]
- 2.Segal P., Insull W., Chambless L.E., Stinnett S., Rosa J.C., Weissfeld L. The association of dyslipoproteinaemia with corneal arcus and xanthelasma. The Lipid Research Clinic's Programme Prevalence Study. Circulation. 1986;73:1108–1118. [PubMed] [Google Scholar]
- 3.Ernst J., Schaefer S.L., Suchan D. Effect of age, gender and menopausal status in plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham offspring study. J. Lipid Res. 1994;35:779–781. [PubMed] [Google Scholar]
- 4.Hammond B., Hess M.L. The oxygen free radical system; Potential mediator of myocardial injury. J. Amer. Coll. Cardiol. 1985;6:215–219. doi: 10.1016/s0735-1097(85)80278-3. [DOI] [PubMed] [Google Scholar]
- 5.Rifai N., King M.E. Immunoturbidimetric assay of Apoliprotein A, Al, All and B in serum. Clin. Chem. 1986;32:957–961. [PubMed] [Google Scholar]
- 6.Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin. Chem. Acta. 1978;90:37–43. doi: 10.1016/0009-8981(78)90081-5. [DOI] [PubMed] [Google Scholar]
- 7.Nandi A., Chatterjee I.B.Assay of superoxide dismutase activity in animal tissue J. Biosci. 198813305–315.10.1007/BF02712155 [Google Scholar]