Abstract
The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol (LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid parameters.
Key words: Coronary Artery Disease, Cholesterol, Apolipoprotein A-1, Apolipoprotein-B
Full Text
The Full Text of this article is available as a PDF (309.1 KB).
References
- 1.Chadha S.L., Radhakrishnan S., Ramachandaran K., Gopinath N. Epidemiological Study of Coronary heart disease in rural population of Gurgaon District (Haryana state) Indian Journal of Community Medicine. 1989;14:141–147. [Google Scholar]
- 2.Chadha S.L., Radhakrishnan K., Shekawat S., Tandon R. A 3-year follow up study of coronary heart disease in Delhi. W.H.O. Bulletin. 1993;7(1):67–72. [PMC free article] [PubMed] [Google Scholar]
- 3.Luthra, K., Vasisht, S., Chhabra, S., Raju, K.R., Agarwal, D.P., Manchanda, S.C. and Srivastava, L.M. L/p/(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls. Indian. J. Clin. Biochem. 13, 12–19, 1998. [DOI] [PMC free article] [PubMed]
- 4.Srinivisan S.R., Berenson G.S. Serum apolipoproteins A-1 and B as markers of coronary artery disease in early life: the Bogalusa Heart study. Clin Chem. 1995;41(1):159–164. [PubMed] [Google Scholar]
- 5.Zak B., Dickenman R.C., White E.G., Burnett H., Chemey P.J. Rapid estimation of free and total cholesterol. Amer. J. Clin. Pathol. 1954;24:1307–1313. doi: 10.1093/ajcp/24.11_ts.1307. [DOI] [PubMed] [Google Scholar]
- 6.Fletchar M.J. A colorimetric method of estimating serum triglycerides. Chim. Acta. 1970;22:393–397. doi: 10.1016/0009-8981(68)90041-7. [DOI] [PubMed] [Google Scholar]
- 7.Bumstein M., Scholwick H.R., Morfin R. Rapid method of isolation of Lipoprotein from human serum by precipitation with polyanions. J. Lipid. Res. 1970;11:583–591. [PubMed] [Google Scholar]
- 8.Rosseneu, M. (1983). Immunonephiometric assay of apolipoproteins. In: Proceedings of the workshop in apolipoprotein quantification. Ed. kenneth Lippel. NIII publication No.83-12266, 305–311.
- 9.Blackbum H., Jacobs D. Coronary disease risk factors. In: Gotto F.G., Middlehoff A.M., Habenicht. G., Juretka A.J.R., Scheyyler K.R., editors. Atherosclerosis VI: Proceedings of the sixth international symposium on Atherosclerosis. Berlin: Springer, Verlag; 1983. pp. 733–744. [Google Scholar]
- 10.Lamarche B., Despires J.P., Moorjani S., Bernard C., Dagenais G.R., Lupein P.J. Triglycerides and HDL-cholestrol as risk factor for ischemic heart disease. Results from the Quebec cardiovascular disease. Atherosclerosis. 1996;119:235–245. doi: 10.1016/0021-9150(95)05653-x. [DOI] [PubMed] [Google Scholar]
- 11.Maciejko J.J., Holmes D.R., Kottke B.A., Zinmeister A.R., Dinh D.M., Mao S.J.T. Apolipoprotein A-1 as marker of a angiographically assessed Coronary Artery Disease. The New England Journal of Medicine. 1983;309(7):385–389. doi: 10.1056/NEJM198308183090701. [DOI] [PubMed] [Google Scholar]
- 12.Bahl V.K., Vaswani M., Thatai D., Wasir H.S. Plasma levels of apolipoproteins A-1 and B in Indian patients… with angiographically defined coronary artery disease. Int. J. Cardiol. 1994;46(2):143–149. doi: 10.1016/0167-5273(94)90035-3. [DOI] [PubMed] [Google Scholar]
- 13.Kottke B.A., Zinsmeister A.R., Holmes D.R., Kneller R.W., Halaway B.J., Halaway B.J., Mao S.J.T. Apolipoproteins and Coronary Artery Disease. Mayo. Clin. Proc. 1986;61:313–320. doi: 10.1016/s0025-6196(12)61947-8. [DOI] [PubMed] [Google Scholar]
- 14.Sharma R., Zaidi S.A., Singh V.S. A study of Apolipoprotein in Myocardial Infarction. The Antiseptic. 1995;92:434–435. [Google Scholar]