Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Jul;81(13):4033–4036. doi: 10.1073/pnas.81.13.4033

Induction of gamma-interferon activity by elevated temperatures in human B-lymphoblastoid cell lines.

M W Taylor, T Long, H Martinez-Valdez, J Downing, G Zeige
PMCID: PMC345362  PMID: 6330733

Abstract

When the human B-lymphoblastoid cell lines GM3299 and GM4408 were heat shocked, elevated levels of antiviral activity were detected. This antiviral activity has been characterized as the result of de novo synthesis of interferon (IFN) gamma. Levels of antiviral activity as high as 20,000 units/ml per 10(6) cells were found after heat treatment. By using anti-IFN-alpha and anti-IFN-gamma sera, it was shown that the high antiviral activity in GM3299 after heat shock is due to a synergistic effect of constitutively produced IFN-alpha and induced IFN-gamma.

Full text

PDF
4033

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adolf G. R., Swetly P. Tumour-promoting phorbol esters inhibit DNA synthesis and enhance virus-induced interferon production in a human lymphoma cell line. J Gen Virol. 1980 Nov;51(Pt 1):61–67. doi: 10.1099/0022-1317-51-1-61. [DOI] [PubMed] [Google Scholar]
  2. Bell J. F., Moore G. J. Effects of high ambient temperature on various stages of rabies virus infection in mice. Infect Immun. 1974 Sep;10(3):510–515. doi: 10.1128/iai.10.3.510-515.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bernheim H. A., Kluger M. J. Fever: effect of drug-induced antipyresis on survival. Science. 1976 Jul 16;193(4249):237–239. doi: 10.1126/science.935867. [DOI] [PubMed] [Google Scholar]
  4. Carmichael L. E., Barnes F. D., Percy D. H. Temperature as a factor in resistance of young puppies to canine herpesvirus. J Infect Dis. 1969 Dec;120(6):669–678. doi: 10.1093/infdis/120.6.669. [DOI] [PubMed] [Google Scholar]
  5. Chang T. W., Testa D., Kung P. C., Perry L., Dreskin H. J., Goldstein G. Cellular origin and interactions involved in gamma-interferon production induced by OKt3 monoclonal antibody. J Immunol. 1982 Feb;128(2):585–589. [PubMed] [Google Scholar]
  6. Covert J. B., Reynolds W. W. Survival value of fever in fish. Nature. 1977 May 5;267(5606):43–45. doi: 10.1038/267043a0. [DOI] [PubMed] [Google Scholar]
  7. Duff G. W., Durum S. K. Fever and immunoregulation: hyperthermia, interleukins 1 and 2, and T-cell proliferation. Yale J Biol Med. 1982 Sep-Dec;55(5-6):437–442. [PMC free article] [PubMed] [Google Scholar]
  8. Familletti P. C., Rubinstein S., Pestka S. A convenient and rapid cytopathic effect inhibition assay for interferon. Methods Enzymol. 1981;78(Pt A):387–394. doi: 10.1016/0076-6879(81)78146-1. [DOI] [PubMed] [Google Scholar]
  9. Fleischmann W. R., Jr, Georgiades J. A., Osborne L. C., Johnson H. M. Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon. Infect Immun. 1979 Oct;26(1):248–253. doi: 10.1128/iai.26.1.248-253.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fleischmann W. R., Jr, Kleyn K. M., Baron S. Potentiation of antitumor effect of virus-induced interferon by mouse immune interferon preparations. J Natl Cancer Inst. 1980 Nov;65(5):963–966. [PubMed] [Google Scholar]
  11. Hanson D. F., Murphy P. A., Silicano R., Shin H. S. The effect of temperature on the activation of thymocytes by interleukins I and II. J Immunol. 1983 Jan;130(1):216–221. [PubMed] [Google Scholar]
  12. Klein G., Vilcek J. Attempts to induce interferon production by IdUrd induction and EBV superinfection in human lymphoma lines and their hybrids. J Gen Virol. 1980 Jan;46(1):111–117. doi: 10.1099/0022-1317-46-1-111. [DOI] [PubMed] [Google Scholar]
  13. Le J., Prensky W., Henriksen D., Vilcek J. Synthesis of alpha and gamma interferons by a human cutaneous lymphoma with helper T-cell phenotype. Cell Immunol. 1982 Sep 1;72(1):157–165. doi: 10.1016/0008-8749(82)90293-3. [DOI] [PubMed] [Google Scholar]
  14. Le J., Vilcek J., Saxinger C., Prensky W. Human T cell hybridomas secreting immune interferon. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7857–7861. doi: 10.1073/pnas.79.24.7857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pang R. H., Yip Y. K., Vilcek J. Immune interferon induction by monoclonal antibody specific for human T cells. Cell Immunol. 1981 Nov 1;64(2):304–311. doi: 10.1016/0008-8749(81)90482-2. [DOI] [PubMed] [Google Scholar]
  16. Roberts N. J., Jr Temperature and host defense. Microbiol Rev. 1979 Jun;43(2):241–259. doi: 10.1128/mr.43.2.241-259.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Saririan K., Nickerson D. A. Enhancement of murine in vitro antibody formation by hyperthermia. Cell Immunol. 1982 Dec;74(2):306–312. doi: 10.1016/0008-8749(82)90031-4. [DOI] [PubMed] [Google Scholar]
  18. Shimizu M., Shimizu Y., Kodama Y. Effects of ambient temperatures on induction of transmissible gastroenteritis in feeder pigs. Infect Immun. 1978 Sep;21(3):747–752. doi: 10.1128/iai.21.3.747-752.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tovey M. G., Begon-Lours J., Gresser I., Morris A. G. Marked enhancement of interferon production in 5-bromodeoxyuridine treated human lymphoblastoid cells. Nature. 1977 Jun 2;267(5610):455–457. doi: 10.1038/267455a0. [DOI] [PubMed] [Google Scholar]
  20. Vaughn L. K., Bernheim H. A., Kluger M. J. Fever in the lizard Dipsosaurus dorsalis. Nature. 1974 Dec 6;252(5483):473–474. doi: 10.1038/252473a0. [DOI] [PubMed] [Google Scholar]
  21. Volckaert-Vervliet G., Billiau A. Induction of interferon in human lymphoblastoid cells by Sendai and measles viruses. J Gen Virol. 1977 Oct;37(1):199–203. doi: 10.1099/0022-1317-37-1-199. [DOI] [PubMed] [Google Scholar]
  22. Weigent D. A., Langford M. P., Smith E. M., Blalock J. E., Stanton G. J. Human B lymphocytes produce leukocyte interferon after interaction with foreign cells. Infect Immun. 1981 May;32(2):508–512. doi: 10.1128/iai.32.2.508-512.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wiranowska-Stewart M., Stewart W. E., 2nd Determination of human leukocyte populations involved in production of interferons alpha and gamma. J Interferon Res. 1981 Feb;1(2):233–244. doi: 10.1089/jir.1981.1.233. [DOI] [PubMed] [Google Scholar]
  24. Yamaguchi T., Handa K., Shimizu Y., Abo T., Kumagai K. Target cells for interferon production in human leukocytes stimulated by sendai virus. J Immunol. 1977 Jun;118(6):1931–1935. [PubMed] [Google Scholar]
  25. von Wussow P., Platsoucas C. D., Wiranowska-Stewart M., Stewart W. E., 2nd Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells. J Immunol. 1981 Sep;127(3):1197–1200. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES