Abstract
Vitamin A status was measured in 50 pre-school children with acute and persistent diarrhoea. It was measured by (a) Fluorometric micromethod and (b) Conjunctival impression cytology (CIC). The results were compared with 25 normal children. Vitamin A status was lower in children with persistent diarrhoea whereas the results were comparable between the children with acute diarrhoea and control subjects.
Key Words: Vitamin A, Acute diarrhoea, Persistent diarrhoea
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References
- 1.Sommer A. Bellagio brief on vitamin A deficiency. Indian Pediatr. 1992;19:1025–1027. [PubMed] [Google Scholar]
- 2.Sachdeva H.P.S., Puri R.K. Vitamin A deficiency and diarrhoea. Indian Pediatr. 1988;25:911–913. [PubMed] [Google Scholar]
- 3.Sommer A., Joanne K., Tarwotjo I. Increased risk of respiratory disease and diarrhoea with pre-existing mild vitamin A deficiency. Am. J. Clin. Nutr. 1984;41:1090–1095. doi: 10.1093/ajcn/40.5.1090. [DOI] [PubMed] [Google Scholar]
- 4.Milton R.L., Reddy V., Naidu A.N. Mild vitamin A deficiency and childhood morbidity —An Indian Experience. Am. J. Clin. Nutr. 1987;46:827–829. doi: 10.1093/ajcn/46.5.827. [DOI] [PubMed] [Google Scholar]
- 5.Vijayraghvan K, Radhaiah G. Effect of massive dose of vitamin A on morbidity and mortality in Indian children. Lancet. 1990;336:1342–1345. doi: 10.1016/0140-6736(90)92895-O. [DOI] [PubMed] [Google Scholar]
- 6.Natadisastra G., Wittpenn J.R., West K.P., Muhilal., Sommer A. Impression cytology for detection of vitamin A deficiency. Arch. Ophthalmol. 1987;105:1224–1228. doi: 10.1001/archopht.1987.01060090082033. [DOI] [PubMed] [Google Scholar]
- 7.Reddy V., Rao V., Arunjyoti, Reddy M. Conjunctival impression cytology for assessment of vitamin A status. Am. J. Clin. Nutr. 1989;50:814–817. doi: 10.1093/ajcn/50.4.814. [DOI] [PubMed] [Google Scholar]
- 8.Gadmoski A.M., Kjolhede C.L., Wittpenn J.R., Bulux J., Rosas A.R. Conjunctival impression cytology (CIC) to detect sub clinical vitamin A deficiency: comparison of CIC with biochemical assessment. Am. J. Clin. Nutr. 1989;49:495–500. doi: 10.1093/ajcn/49.3.495. [DOI] [PubMed] [Google Scholar]
- 9.Mahalnabis D., Wahed M.A., Islam M., et al. Conjunctival impression Cytology fails to detect sub clinical vitamin A deficiency in young children. J. Nutr. 1995;125:1869–1874. doi: 10.1093/jn/125.7.1869. [DOI] [PubMed] [Google Scholar]
- 10.Egbert P., Lauber S., Maurice D.M. A simple conjunctival biopsy. Am. J. Ophthalmol. 1977;84:798–801. doi: 10.1016/0002-9394(77)90499-8. [DOI] [PubMed] [Google Scholar]
- 11.Driskell W.J., Hewett S., Basher M.M. Evaluation of a direct fluorometric method for the determination of serum retinol. Clin. Chem. 1986;32:867–869. [PubMed] [Google Scholar]
- 12.Scheffer C.G., Tseng. Impression cytology and squamous metaplasia. Ophthalmology. 1985;92:728–733. doi: 10.1016/s0161-6420(85)33967-2. [DOI] [PubMed] [Google Scholar]
- 13.Shultz E.K. Selection and interpretation of laboratory procedures. In: Burtis CA, Ashwood AR, editors. Tietz Text book of Clinical Chemistry. 3rd ed. Philadelphia: WB Saunders; 1999. pp. 310–319. [Google Scholar]
- 14.WHO Tech Report series (1982) Control of vitamin A deficiency and xerophthalmia. No. 672. [PubMed]
- 15.Indirabai K., Bhatt V., Vaidyanathan K. Epidemiological survey for prevalence of xerophthalmia. Indian Pediatr. 1986;23:135–139. [PubMed] [Google Scholar]
- 16.Natadisastra G., Wittpenn J.R., West K.P., Muhilal, Sommer A. Impression cytology: A practical index of vitamin A status. Am. J. Clin. Nutr. 1988;48:695–701. doi: 10.1093/ajcn/48.3.695. [DOI] [PubMed] [Google Scholar]
- 17.Moneseme O.A., Luzeau R., Wittpenn J.R., Hanek A., Sommer A. Impression cytology detects sub clinical vitamin A deficiency. Am. J. Clin. Nutr. 1988;47:875–878. doi: 10.1093/ajcn/47.5.875. [DOI] [PubMed] [Google Scholar]
- 18.Faechem R.G. Vitamin A deficiency and diarrhoea: A review of interrelationships and their implications for the control of xerophthalmia and diarrhoea. Trop. Disease Bulletin. 1987;84(3):R1–R16. [Google Scholar]
- 19.Agarwal D.K., Singh S.V., Gupta V., Agarwal K.N. Vitamin A status in early childhood diarrhoea, respiratory infection and in maternal and cord blood. J. Trop. Pediatr. 1996;42:12–14. doi: 10.1093/tropej/42.1.12. [DOI] [PubMed] [Google Scholar]