Skip to main content
PMC home page
Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 2005 Jul;20(2):154–157. doi: 10.1007/BF02867417

Changes in levels of serum glycoproteins in major depressive disorders

Mukesh Nandave 1,✉, S K Ojha 1, Ranjit Kaur 2
PMCID: PMC3453833  PMID: 23105550

Abstract

The present study deals with estimation of levels of fractions of serum glycoproteins, protein bound hexose (PBH), protein bound hexosamine (PBHex), protein bound fucose (PBF), protein bound sialic acid (PBS) and protein bound carbohydrate (PBC) in thirty patients of Major Depressive Disorders (MDD) in comparison with thirty normal subjects. In patients of MDD, the level of PBH, PBHex, PBF, PBS and PBC were significantly higher as compared to the normal subjects (p<0.05). In patients, of MDD, after one-month treatment with fluoxetine, the levels of PBH, PBHex, PBF, PBS and PBC were significantly decreased as compared to the levels of these fractions in same patients of MDD before beginning of the treatment (p<0.05). Based on findings of the present study, it can be concluded that changes in the level of serum glycoproteins level before and after treatment with fluoxetine can be correlated with clinical status of MDD.

Key Words: Major Depressive Disorders, Serum Glycoproteins

Full Text

The Full Text of this article is available as a PDF (322.9 KB).

References

  • 1.Sharma N.C., Sur B.K. Serum fucose and sialic acid levels in children and adults under normal and pathophysiological condition. Indian J. Med. Res. 1967;55:380–384. [PubMed] [Google Scholar]
  • 2.Singh U., Solanki R.L., Anand V.K., Ramdeo I.N. Serum glycoproteins in pulmonary tuberculosis. Indian J. Med. Res. 1989;89:255–260. [PubMed] [Google Scholar]
  • 3.Jakab L., Pozsonyi T., Feher J. Serum glycoproteins in autoimmune diseases. Acta. Med. Acad. Sci. Hung. 1976;33:161–169. [PubMed] [Google Scholar]
  • 4.Tandon S.K., Solanki R.L., Ramdeo I.N., Anand V.K., Singh U. A study of serum glycoprotein in cardiovascular disorders. Indian J. Med. Res. 1983;37:223–225. [PubMed] [Google Scholar]
  • 5.Dutt M., Chatterjee A.K., Khanade J.M., Rajan S.R. Serum glycoproteins in patients of ischemic heart disease and normal controls. Indian J. Med. Res. 1975;63:282–285. [PubMed] [Google Scholar]
  • 6.Anand V.K., Solanki R.L., Ramdeo I.N., Tandon S.K. A study of serum glycoproteins in diabetes mellitus. J. Assoc. Physicians India. 1985;33:273–275. [PubMed] [Google Scholar]
  • 7.Bhuvarahamurthy V., Balasubramanian N., VijayaKumar S., Govindswamy S. Effect of radiation on serum glycoproteins and glycosidases in patients with cervical carcinoma. Int. J. Gynaecol. Obstet. 1995;48:49–54. doi: 10.1016/0020-7292(94)02247-X. [DOI] [PubMed] [Google Scholar]
  • 8.Upadhya S., Upadhya S., Prabhu K.S. Serum glycoconjugates and ceruloplasmin in cancer of uterine cervix. Indian J. Clin. Biochem. 2002;17:20–24. doi: 10.1007/BF02867936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Solanki R.L., Ramdeo I.N., Sachdev K.N. Serum protein bound fucose in diagnosis of breast malignancy. Indian J. Med. Res. 1978;67:786–791. [PubMed] [Google Scholar]
  • 10.Oss C.J., Bronson P.M., Border J.R. Changes in the serum alpha glycoprotein distribution in trauma patients. J. Trauma. 1975;15:451–455. doi: 10.1097/00005373-197505000-00013. [DOI] [PubMed] [Google Scholar]
  • 11.McMillan D.E., Donaldson C.L. Changes in serum proteins, viscosity, and protein-bound carbohydrates during prolonged bedrest. Aviat. Space Environ. Med. 1975;46:132–135. [PubMed] [Google Scholar]
  • 12.Weimer H.E., Moshin J.R. Comparative effects of intramuscular injections of ACTH, cortisone, and saline on serum glycoprotein levels. Proc. Soc. Exp. Biol. Med. 1953;84:34–37. doi: 10.3181/00379727-84-20532. [DOI] [PubMed] [Google Scholar]
  • 13.Varma R.S., Varma R., Hoshino A.Y. Serum and mucopolysaccharide level in psychiatric patients. Neurosci. Lett. 1979;14:349–354. doi: 10.1016/0304-3940(79)96173-1. [DOI] [PubMed] [Google Scholar]
  • 14.Seal V.S., Eist H. Elevation of serum protein bound carbohydrate and heptaglobin in schizophrenia. Clin. Chem. 1966;12:709–709. [PubMed] [Google Scholar]
  • 15.Mehta N.G., Venkatraman A. Serum glycoproteins levels and disease—an evaluation. Indian J. Med. Res. 1975;63:970–976. [PubMed] [Google Scholar]
  • 16.Winzler R.J. In: Determinations of serum glycoproteins, Methods of biochemical analysis. Glick D., editor. Newyork, USA: Interscience Publishers; 1955. pp. 279–311. [DOI] [PubMed] [Google Scholar]
  • 17.Varma R., Hoshino A.Y. Serum glycoprotein in schizophrenia. Carbohydr. Res. 1980;82:343–351. doi: 10.1016/S0008-6215(00)85708-0. [DOI] [PubMed] [Google Scholar]
  • 18.Henry, R.J., Cannon, D.C. and Winkelman, J.W. (1974) Clinical chemistry: principles and techniques, Harper and Row Publishers Inc. page 461.
  • 19.Dische Z., Shettles L.B., Osnos M. Neutral mucopolysaccharide of the human cervical mucus. J. Biol. Chem. 1951;192:589–593. [PubMed] [Google Scholar]
  • 20.Seibert F.B., Seibert M.V., Atno A.J., Campbell H.W. J. Clin. Invest. 1949;26:90–94. doi: 10.1172/JCI101794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21.Kremer J.M.H., Wilting J., Janseen L.M.H. Drug binding to human alpha-1 acid glycoprotein in health and disease. Pharmacol. Rev. 1988;40:1–14. [PubMed] [Google Scholar]

Articles from Indian Journal of Clinical Biochemistry are provided here courtesy of Springer

RESOURCES