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Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 2006 Sep;21(2):165–168. doi: 10.1007/BF02912935

Study of serum lipid profile in pregnancy induced hypertension

Jayanta De 1,✉, Ananda Mukhopadhyay 2, Pradip Kumar Saha 1
PMCID: PMC3453987  PMID: 23105637

Abstract

Four groups of subjects: normal healthy normotensive nonpregnant women (Group A), normal normotensive pregnant women (Group B), women with preeclamptic toxaemia (Group C) and eclamptic women (Group D): with fifty subjects in each group, were investigated for serum lipid profile in the third trimester of pregnancy. There was significant increase in serum triglyceride and VLDL cholesterol leve as well as decrease in LDL cholesterol in normal pregnancy, while total cholesterol and HDL cholesterol levels did not show any statistically significant alteration. The preeclampsia (Group C) was associated with a significant rise in triglyceride and VLDL cholesterol and fall in HDL cholesterol concentration, while eclamptic women showed significant fall in HDL cholesterol and rise in LDL cholesterol as compared to normal pregnant women. However, interestingly, elevation of the ratios of total cholesterol: HDL cholesterol and triglyceride: HDL cholesterol as well as diminuition of the ratio of HDL cholesterol: VLDL cholesterol showed statistical significance in pregnancy induced hypertension in both Groups C and D, while eclamptic women showed significant elevation of LDL cholesterol: HDL cholesterol ratio in addition.

Key Words: Blood Lipids, Dyslipidemia, Normal Pregnancy, Pre-eclampsia, Eclampsia, PIH

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References

  • 1.Dutta D.C. Hypertensive disorders in pregnancy. In: Konar H.L., editor. Textbook of Obstetrics. 5th edition. Kolkata: New Central Book Agency; 2001. pp. 234–55. [Google Scholar]
  • 2.Robson S.C. Hypertension and renal disease in pregnancy. In: Edmonds D.K., editor. Dewhurst's Textbook of Obstetrics and Gynaecology for postgraduates. 6th edition. New York: Blackwell Science Ltd.; 1999. pp. 167–9. [Google Scholar]
  • 3.Chiang A.N., Yang M.L., Hung J.H., Chon P., Shyn S.K., Ng H.T. Alterations of serum lipid levels and their biological relevances during and after pregnancy. Life Sci. 1995;56(26):2367–75. doi: 10.1016/0024-3205(95)00230-4. [DOI] [PubMed] [Google Scholar]
  • 4.Glueck C.J., Fallet R.W., Scheel D. Effects of oestrogenic compounds on triglyceride kinetics. Metabolism. 1975;24:537–45. doi: 10.1016/0026-0495(75)90078-5. [DOI] [PubMed] [Google Scholar]
  • 5.Adegoke O.A., Lyare E.E., Gbenebitse S.O. Fasting plasma glucose and cholesterollevels in pregnant Nigerian women. Niger. Postgrad. Med. J. 2003;10(1):32–6. [PubMed] [Google Scholar]
  • 6.Enquobahrie D.A., Williams M.A., Butler C.L., Frederick I.O., Miller R.S., Luthy D.A. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am. J. Hypertens. 2004;17(7):574–81. doi: 10.1016/j.amjhyper.2004.03.666. [DOI] [PubMed] [Google Scholar]
  • 7.Cekmen M.B., Erbagci A.B., Balat A., Duman C., Maral H., Ergen K., Osden M., Balat O., Kuskay S. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. Clin. Biochem. 2003;36(7):575–8. doi: 10.1016/S0009-9120(03)00099-7. [DOI] [PubMed] [Google Scholar]
  • 8.Mikhail M.S., Basu J., Palan P.R., Furgiusle J., Romney S.L., Anyaegbunam A. Lipid profile in women with preeclampsia: relationship between plasma triglyceride levels and severity of preeclampsia. J. Assoc. Acad. Minor Phys. 1995;6(1):43–5. [PubMed] [Google Scholar]
  • 9.Sattar N., Bendomir A., Berry C., Shepherd J., Greer I.A., Packard C.J. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet. Gynecol. 1997;89(3):403–8. doi: 10.1016/S0029-7844(96)00514-5. [DOI] [PubMed] [Google Scholar]
  • 10.Kokia E., Barkai G., Reichman B., Segal P., Goldman B., Mashiach S. Maternal serum lipid profile in pregnancies complicated by hypertensive disorders. J. Perinat. Med. (Germany) 1990;18(6):473–8. doi: 10.1515/jpme.1990.18.6.473. [DOI] [PubMed] [Google Scholar]
  • 11.Yamaguchi K. Triglycerides and apoproteins in toxaemia of pregnancy. Nippon Sanka Fujika Gakkai Zasshi (Japan) 1988;40(2):1875–82. [PubMed] [Google Scholar]
  • 12.Hubel C.A., Lyall F., Weissfeld L., Gandley R.E., Roberts J.M. Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism. 1998;47(10):1281–8. doi: 10.1016/S0026-0495(98)90337-7. [DOI] [PubMed] [Google Scholar]
  • 13.Bradley R., Crook D. Pregnancy, oral contraception and hormone replacement therapy. In: Marshall W.J., Bangert S.K., editors. Textbook of Clinical Biochemistry: Metabolic and Clinical aspects. 1st edition. London: Churchill Livingstone; 1995. pp. 413–22. [Google Scholar]
  • 14.Kaaja R., Tirkkanen M.J., Viinnkka L., Ylikorkala O. Serum lipoproteins, insulin and urinary prostanoid metabolites in normal and hypertensive pregnant women. Obstet. Gynecol. 1995;85(3):353–6. doi: 10.1016/0029-7844(94)00380-V. [DOI] [PubMed] [Google Scholar]
  • 15.Teichmann A.T., Wieland H., Cremer P., Knlow G., Mehle U. Serum lipid and lipoprotein concentrations in pregnancy and at onset of labour in normal and complicated pregnancies caused by hypertensive gestosis and fetal growth retardation. Geburtshilfe Frauenheilkd (Germany, West) 1988;48(3):134–9. doi: 10.1055/s-2008-1035711. [DOI] [PubMed] [Google Scholar]
  • 16.Knopp R.H., Warth M.R., Charles D., Childs M., Li J.R., Mabuchi H., Von M.I.A. Lipoprotein metabolism in pregnancy, fat transport to the fetus and the effects of diabetes. Biol. Neonate (Switzerland) 1986;50(6):297–317. doi: 10.1159/000242614. [DOI] [PubMed] [Google Scholar]
  • 17.Potter J.M., Netel P.J. The hyperlipidaemia of pregnancy in normal and complicated pregnancies. Am. J. Obstet. Gynaecol. (United States) 1979;133(2):165–70. doi: 10.1016/0002-9378(79)90469-1. [DOI] [PubMed] [Google Scholar]
  • 18.Arbogast B.W., Leeper S.C., Merrick R.D., Olive K.E., Taylor R.N. Which plasma factors bring about disturbance of endothelial function in preeclampsia? Lancet. 1994;343(8893):340–1. doi: 10.1016/S0140-6736(94)91169-X. [DOI] [PubMed] [Google Scholar]
  • 19.Gratacos E., Casals E., Gomez O., Llurba E., Mercader I., Cararach V., Cabero L. Increased susceptibility to low density lipoprotein oxidation in women with a history of preeclampsia. British Journal of Obst. & Gynae. 2003;110(4):400–4. [PubMed] [Google Scholar]
  • 20.Wakatsuki A., Ikenoue N., Okatani Y., Shinohara K., Fukaya T. Lipoprotein particles in preeclampsia: susceptibility to oxidative modification. Obstet. Gynecol. 2000;96(1):55–9. doi: 10.1016/S0029-7844(00)00858-9. [DOI] [PubMed] [Google Scholar]
  • 21.Barden A., Ritchie J., Walters B., Michael C., Rivera J., Mori T., Croft K., Beilin L. Study of plasma factors associated with neutrophil activation and lipid peroxidation in preeclampsia. Hypertension. 2001;38(4):803–8. doi: 10.1161/hy1101.092969. [DOI] [PubMed] [Google Scholar]
  • 22.Lorentsen B., Henriksen T. Plasma lipids and vascular dysfunction in pre-eclampsia. Semin Reprod. Endocrinol. 1998;16(1):33–39. doi: 10.1055/s-2007-1016250. [DOI] [PubMed] [Google Scholar]

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