Abstract
In the present study which was aimed to see the effect of zinc on pentylenetetrazole induced convulsive threshold in rats we found that zinc sulfate 100 μg intracerebroventricularly) and pentylenetetrazole (50 mg/kg intraperitoneally) produced dose related seizure activity; however, pretreatment with zinc decreased the threshold, increased the severity, incidence of multiple seizures and total duration of pentylenetetrazole induced seizures. Diazepam (5 mg/kg intraperitoneally) pretreatment increased the threshold and lowered the incidence of convulsions in zinc induced seizures which further confirms that the convulsive effect of zinc is through inhibition of gamma aimino butyric acid.
Key Words: Zinc, Pentylentetrazole, Diazepam, GABA
Full Text
The Full Text of this article is available as a PDF (351.4 KB).
References
- 1.Purpura D.P., Penry J.K., Tower D.B., Woodbury D.M., Walter R.D. Experimental models of epilepsy. New York: Raven Press; 1972. [Google Scholar]
- 2.Noble E.P., Wurtman R.T., Axelrod J. A simple and rapid method for injection of H3-norepinephrine into the lateral ventricle of the rat brain. Life Sciences. 1967;6:281–291. doi: 10.1016/0024-3205(67)90157-9. [DOI] [PubMed] [Google Scholar]
- 3.Pei Y.Q., Koyama I. Features of seizures and behavioural changes induced by intrahippocampal injection of zinc sulfate in the rabbit: a new experimental model of epilepsy. Epilepsia. 1986;27(3):183–188. doi: 10.1111/j.1528-1157.1986.tb03526.x. [DOI] [PubMed] [Google Scholar]
- 4.Rosen A.D., Frumin N.V. Focal epileptogenesis after intracortical haemoglobin injection. Experimental Neurology. 1979;66:277–284. doi: 10.1016/0014-4886(79)90080-3. [DOI] [PubMed] [Google Scholar]
- 5.Reid S.A., Sypert G.W., Goggs W.M. Histopathology of the ferri-induced chronic epileptic focus in cat. Exp. Neurol. 1979;66:205–210. doi: 10.1016/0014-4886(79)90075-X. [DOI] [PubMed] [Google Scholar]
- 6.Lange S.C., Nealsey E.J., Wyler A.R. Neuronal activity in chronic ferric chloride epileptic foci in cats and monkeys. Epilepsia. 1980;21:251–254. doi: 10.1111/j.1528-1157.1980.tb04070.x. [DOI] [PubMed] [Google Scholar]
- 7.Willmore I.J. Recurrent seizure induced by cortical iron injection, a model of post-traumatic epilepsy. Ann. Neurol. 1978;4:329–333. doi: 10.1002/ana.410040408. [DOI] [PubMed] [Google Scholar]
- 8.Pei Y., Xie S. A new experimental model of epilepsy. Yao Hsuch Hsuch Pao. 1980;15:113–117. [Google Scholar]
- 9.Tokuoka S. Neurochemical consideration on the alleviating effect of caudal resection of the pancreas on epileptic seizure relationship of zinc metabolism to brain excitability. Bull Yamaguchi Med. Sch. 1967;14:1–18. [Google Scholar]
- 10.Alley N.C., Killam E.K., Fisher G.I. The influence of D-penicillamine treatment upon seizure activity and trace metal state in the Senegalese baboon, Papio papio. J. Pharmacol. Exp. Ther. 1981;217:138–146. [PubMed] [Google Scholar]
- 11.Papavasiion P.S., Kutt M., Miller S.T., Rosal V., Wang Y.Y., Aronson R.B. Seizure disorders and trace metal, manganese tissue levels in treated epileptics. Neurology. 1979;29:1466–1479. doi: 10.1212/wnl.29.11.1466. [DOI] [PubMed] [Google Scholar]
- 12.Pei Y.Q., Zhao D., Haung J., Cao L. Zinc-induced seizures: a new experimental model of epilepsy. Epilepsia. 1983;24:169–176. doi: 10.1111/j.1528-1157.1983.tb04876.x. [DOI] [PubMed] [Google Scholar]
- 13.Mares P., Schickerova R. Seizures elicited by subcutaneous injection of Metrazole during ontogenesis in rats. Act. Nerv. Super. 1980;22:264–268. [PubMed] [Google Scholar]
- 14.Lacoste L., Bartolucci S. Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex. Can. J. Physiol. Pharmacol. 1987;66:1135–1138. doi: 10.1139/y88-186. [DOI] [PubMed] [Google Scholar]