Abstract
Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control. Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD±77) mg/dl (P<0.001) as compared to control. Levels of HDL cholesterol were found to be significantly low 20 (±11) mg/dl (p<0.001) in all the groups. LDL cholesterol showed an increase 104 (±30) mg/dl as compared to control group which is not statistically significant. Present study reveals that, CRF patients show an uniform dyslipidemia irrespective of etiologies leading to CRF. This dyslipidemia is also independent of serum creatinine levels. Although, these lipid abnormalities may not solely cause mortality in CRF patients, they may act as modulators in accelerating atherogenesis which in turn cause early mortality in CRF patients.
Keywords: Chronic Renal Failure (CRF), High Density Lipids (HDL), Low Desity Lipids (LDL), Dyslipidemia, Atherogenesis
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References
- 1.Bagdade J.D., Porte D.J.R., Bierman E.L. Hypertriglyceridemia a metabolic consequence of chronic renal failure. New Eng. J. Med. 1968;264:181–185. doi: 10.1056/NEJM196807252790403. [DOI] [PubMed] [Google Scholar]
- 2.Chan M.K., Varghese Z., Moorhead J.F. Lipid abnormalities in Uremia, dialysis and transplantation. Kidney Int. 1981;19:625–637. doi: 10.1038/ki.1981.62. [DOI] [PubMed] [Google Scholar]
- 3.Kasiske B.L., O'Donnell M.P., Schmitz P.G., Kimyoungki, et al. Renal injury of diet induced hypercholesterolemia in rats. Kidney Int. 1990;37:808–891. doi: 10.1038/ki.1990.62. [DOI] [PubMed] [Google Scholar]
- 4.Jones S.L., Close C.F., Mattoc M.B., Jarrett R.J., Keen H, Viberti G.C. Plasma lipid and coagulation factor concentrations in insulin dependent diabetics with microalbuminura. Br. Med. J. 1989;298:487–490. doi: 10.1136/bmj.298.6672.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Kassike B.L. Relationship between vascular disease and age associated changes in human kidney. Kidney Int. 1987;31:1153–1159. doi: 10.1038/ki.1987.122. [DOI] [PubMed] [Google Scholar]
- 6.Friedwald W.T., Levy R.I., Fredrickson D.S. Estimation of concentration of low density lipoproten cholesterol without the use of preparative ultracentrifuge. Clin Chem. 1972;18:499–499. [PubMed] [Google Scholar]
- 7.Keane W.F. Lipids and Kidney. Kidney Int. 1994;31:1153–1159. doi: 10.1038/ki.1994.349. [DOI] [PubMed] [Google Scholar]
- 8.Joven J., Vileela E., Ahmad S., Cheung M.C., Brunzell J.D. Lipoprotein heterogeneity in end-stage renal disease. Kidney Int. 1993;43:410–418. doi: 10.1038/ki.1993.60. [DOI] [PubMed] [Google Scholar]
- 9.Senti M., Ramero R., Pedro-Botet J., Pellegro A., Nogues X., Rubies-Prat J. Lipoprotein abnormalities in hyperlipidemic and normolipidemic men on hemodialysis with chronic renal failure. Kidney Int. 1992;41:1394–1399. doi: 10.1038/ki.1992.204. [DOI] [PubMed] [Google Scholar]
- 10.Ritz E., Augustein J, Bommer J., Gnasso A., Haberbosh W. Should hyperlipemia of renal failure be treated? Kidney Int. 1985;28(Suppl, 17):S?84–S?87. [PubMed] [Google Scholar]