Abstract
Serum β2-microglubin (β2-m) levels were measured in oral carcinoma patients and compared with normal healthy controls. It was observed that there was a significant rise in serum β2-microglobulin in oral carcinoma patients. Progressively higher values were obtained as the cancer advanced clinically. Therefore the estimation of serum β2-microglobulin may be useful as one of a battery of tests in the assessment of oral carcinoma patients.
Key Words: Oral carcinoma, β2-microglobulin
Full Text
The Full Text of this article is available as a PDF (234.0 KB).
References
- 1.Berggard I., Bearn A.G. Isolation and properties of a low molecular weight β2-globulin occurring in human biological fluids. J. Biol. Chem. 1968;243:4095–4103. [PubMed] [Google Scholar]
- 2.Child J.A., Spati B., Illingworth S., Barnard D., Corbett S., Simmons A.V., Stone J., Worthy T.S., Cooper E.H. Serum beta 2 microglobulin and C-reactive protein in the monitoring of lymphomas. Cancer. 1980;45:318–326. doi: 10.1002/1097-0142(19800115)45:2<318::AID-CNCR2820450220>3.0.CO;2-C. [DOI] [PubMed] [Google Scholar]
- 3.Anil S., Beena V.T., Nair R.G., Vijayakumar T. Evaluation of serum β2-micr in premalignant and malignant lesions of the oral cavity. Oral. Surg. Oral. Med. Oral. Pathol. 1994;79:750–752. doi: 10.1016/s1079-2104(05)80311-7. [DOI] [PubMed] [Google Scholar]
- 4.Scully C. Serum β2-microglobulin in oral malignancy and premalignancy. J. Oral. Pathol. 1981;10:354–357. doi: 10.1111/j.1600-0714.1981.tb01287.x. [DOI] [PubMed] [Google Scholar]
- 5.Vinzenz K., Schonthal E., Zekert F., Wunderer S. Diagnosis of head and neck carcinomas by means of immunological tumour markers. J. Cranio. Max. Fac. Surg. 1987;15:270–277. doi: 10.1016/S1010-5182(87)80066-5. [DOI] [PubMed] [Google Scholar]
- 6.Beta 2-microglobulin EIA kit, Immunotech, France, booklet on directions for use.
- 7.Shuster J., Gold P., Poulik M.D. β2-microglobulin levels in cancerous and other disease states. Clin. Chim. Acta. 1976;67:307–313. doi: 10.1016/0009-8981(76)90339-9. [DOI] [PubMed] [Google Scholar]
- 8.Evrin P.E., Wibell L. Serum β2-microglobulin in various disorders. Clin. Chim. Acta. 1973;43:183–187. doi: 10.1016/0009-8981(73)90449-X. [DOI] [PubMed] [Google Scholar]
- 9.Kithier K., Cejka J., Belamariac J., Al-Sarraf M., Peterson W.D., Vaitkevicius V.K., Poulik M.D. β2-microglobulin: Occurrence in fetal life and malignancy. Clin. Chim. Acta. 1974;52:293–299. doi: 10.1016/0009-8981(74)90113-2. [DOI] [PubMed] [Google Scholar]
- 10.Miyata T., Jadoul M., Kurokawa K., Strihou C.V.Y. Beta-2 microglobulin in renal disease. J. Am. Soc. Nephrol. 1998;9:1723–1735. doi: 10.1681/ASN.V991723. [DOI] [PubMed] [Google Scholar]
- 11.Eley B.S., Hughes J., Potgieter S., Keraan M., Burgess J., Hussey G.D. Immunological manifestations of HIV-infected children. Ann. Trop. Paediatr. 1999;19:3–7. doi: 10.1080/02724939992572. [DOI] [PubMed] [Google Scholar]
- 12.Pita O., Frezzolini A., Cianetti A., Sanctis G., Fontana L., Bottari V. Squamous cell carcinoma related antigen (SCCr-Ag), sICAM-1 and beta 2-microglobulin are useful markers of disease activity in psoriasis. Acta. Derm. Venereol. 1999;79:132–135. doi: 10.1080/000155599750011354. [DOI] [PubMed] [Google Scholar]
- 13.Morra E. The biological markers of non-Hodgkin's lymphomas: their role in diagnosis, prognostic assessment and therapeutic strategy. Int. J. Biol. Markers. 1999;14:149–153. doi: 10.1177/172460089901400305. [DOI] [PubMed] [Google Scholar]
- 14.Rodriguez J., Cortes J., Talpaz M., O'Brien S., Smith T.L., Rios M.B., Kantarjian H. Serum β2-microglobulin levels are a significant prognostic factor in philadelphia chromosome—positive chronic myelogenous leukemia. Clin. Cancer. Res. 2000;6:147–152. [PubMed] [Google Scholar]
- 15.Amlot P.L., Adinolfi M. Serum β2-microglobulin and its prognostic value in lymphomas. Eur. J. Cancer. 1979;15:791–796. doi: 10.1016/0014-2964(79)90155-5. [DOI] [PubMed] [Google Scholar]