Abstract
Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below 9.0 gm/d1. Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (TIBC) were significantly higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during pregnancy to affect a healthy outcome.
Key Words: Iron, Copper, Zinc, Pregnancy, Newborn, Iron Deficiency Anemia
Full Text
The Full Text of this article is available as a PDF (360.4 KB).
References
- 1.Black R.E. Micronutrients in pregnancy. Br. J. Nutr. 2001;85(2):193–197. doi: 10.1079/bjn2000314. [DOI] [PubMed] [Google Scholar]
- 2.Naeye R., Blanc W., Paul C. Affects of maternal nutrition on human fetus. Pediatr. 1973;52:494–503. [PubMed] [Google Scholar]
- 3.Brock N.R., Letsky E.A., White S.A., Shenkin A. Iron status in pregnant women: which measurements are valid? Br J. Haematol. 1998;103(3):817–24. doi: 10.1046/j.1365-2141.1998.01035.x. [DOI] [PubMed] [Google Scholar]
- 4.Sharma D.C., Kiran R., Ramnath V., Khushlani K., Singh P.P. Iron deficiency anemia in vegetarian mothers and their newborns. Ind. J. Clin. Biochem. 1994;9:100–102. doi: 10.1007/BF02869583. [DOI] [Google Scholar]
- 5.Perveen S., Altaf W., Vohra N., Bautista M.L., Harper R.G., Wapnir R.A. Effect of gestational age on cord blood plasma copper, zinc, magnesium, and albumin. Early Hum. Dev. 2002;69(1–2):15–23. doi: 10.1016/S0378-3782(02)00024-5. [DOI] [PubMed] [Google Scholar]
- 6.Kolsteren P., Rahman S.R., Hilderband K., Diniz A. Treatment for Iron deficiency anemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. Eur. J. Clin. Nutr. 1999;53(2):102–106. doi: 10.1038/sj.ejcn.1600684. [DOI] [PubMed] [Google Scholar]
- 7.Sehifman R.B., Rivers S.L., Finley P.R., Thies C. RBC, zinc, protoporphyrin to screen blood donors for iron deficiency anemia. JAMA. 1982;22(16):2012–2015. doi: 10.1001/jama.248.16.2012. [DOI] [PubMed] [Google Scholar]
- 8.Sharma D.C., Ajmera P., Sharma S., Sharma P. Association between serum iron and copper in pregnant anemic vegetarian women. SDMH Jour. 1999;23(1):37–39. [Google Scholar]
- 9.Salgneiro J., Zubillage M., Lysianek A., Sarabia M.I., Calmanonici G., Caro R., Paoli T., Hager A., Weill R., Boccio J. Zinc: concepts on an essential micronutrient. A trphysiol Pharmacol. Ther Latinoam. 1999;49(1):1–12. [PubMed] [Google Scholar]
- 10.Dacie J.V., Lewis S.M. Practical Hematology. 8th Ed. Edinburg: Churchil Livingstone; 1994. pp. 49–59. [Google Scholar]
- 11.Dacie J.V., Lewis S.M. Practical Hematology. 8th Ed. Edinburg.: Churchil Livingstone; 1994. pp. 60–82. [Google Scholar]
- 12.Gambling L., Danzeisen R., Fosset C., Andersen H.S., Dunford S., Srai S.K., Ardle M.H.J. Iron and copper interactions in development and the effect on pregnancy outcome. J. Nutr. 2003;133(5):1554S–1556S. doi: 10.1093/jn/133.5.1554S. [DOI] [PubMed] [Google Scholar]
- 13.Yadric M.K., Kenney M.A., Winterfeldt E.A. Iron, copper and zinc status: Response to supplementation with zinc or zinc and Iron in adult females. Am. J. clin. Nutr. 1998;49:145–150. doi: 10.1093/ajcn/49.1.145. [DOI] [PubMed] [Google Scholar]
- 14.Balai K.S., Pendse V., Gupta R., Gupta S. Effect of maternal anemia on iron status of the newborn. Indian J. Matern. Child Health. 1992;3(2):54–56. [PubMed] [Google Scholar]
- 15.Islam M.A., Hemalatha P., Bhaskaran P., Kumar P.A. Leucocyte and plasma zinc in maternal and cord blood: their relationship to period of gestation and birth weight. Nutr. Res. 1994;14:353–360. doi: 10.1016/S0271-5317(05)80174-5. [DOI] [Google Scholar]
- 16.Sachdeva R., Mann S.K. Impact of nutrition counselling and supplements on the mineral nutriture of rural pregnant women and their neonates. Indian Pediatr. 1994;31(6):643–649. [PubMed] [Google Scholar]
- 17.Metcoff, Costiloe J.P., Crosby W. Maternal nutrition and fetal outcome. Am. J. Clin. Nutr. 1981;34:708–721. doi: 10.1093/ajcn/34.4.708. [DOI] [PubMed] [Google Scholar]
- 18.Sandstorm B. Micronutrient Interactions: effects on absorption and bioavailability. Br. J. Nutr. 2001;8S(2):181–185. [PubMed] [Google Scholar]
- 19.Henkin I.R., Marshall J.R., Meret S. Materno fetal metabolism of copper and zinc at term. Am. J. Obstet. Gynecol. 1971;110:131–34. doi: 10.1016/0002-9378(71)90234-1. [DOI] [PubMed] [Google Scholar]
- 20.Aggett P.J., Harris J.T. Current status of zinc in health and disease states. Arch. Dis. Chil. 1979;54:909–917. doi: 10.1136/adc.54.12.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Bro S., Berendtsen H., Norgaard J., Host A., Jorgensen P.J. Serum zinc and copper concentrations in maternal and umbilical cord blood: Relation to course and outcome of pregnancy. Scand. J. Clin. Lab. Invest. 1988;48:805–811. doi: 10.3109/00365518809088764. [DOI] [PubMed] [Google Scholar]
- 22.Swanson C.A., King J.C. Reduced serum zinc concentration during pregnancy. Obstet. Gynecol. 1983;62:313–316. doi: 10.1097/00006250-198309000-00010. [DOI] [PubMed] [Google Scholar]
- 23.Garg H.K., Singhal K.C., Arshad Z. Effect of oral zinc supplementation on copper and Hemoglobin levels in pregnant women. Ind. J. Physiol. Pharmacol. 1994;38(4):272–276. [PubMed] [Google Scholar]
- 24.Ece A., Uyanik B. S., Iscan A., Ertan P., Yigitoglu M.R. Increased serum copper and decreased serum zinc levels in children with Iron deficiency anemia. Biol. Trace Elem. Re. 1997;59(1–3):31–39. doi: 10.1007/BF02783227. [DOI] [PubMed] [Google Scholar]
- 25.Dawson, E.B., Albers, J. and Ganity, M.W.J. (1989) Serum zinc changes due to Iron supplementation in teen-age pregnancy.Am. J. Clin. Nutr. 848–852. [DOI] [PubMed]
- 26.Prasad A.S., Brewer G.J., Schoomaker E.B., Rabbani P. Hypocupremia induced by zinc therapy in adults. JAMA. 1978;240:2166–2168. doi: 10.1001/jama.240.20.2166. [DOI] [PubMed] [Google Scholar]