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Indian Journal of Clinical Biochemistry logoLink to Indian Journal of Clinical Biochemistry
. 2004 Jul;19(2):80–83. doi: 10.1007/BF02894261

Oxidant-antioxidant status in colorectal cancer patients—Before and after treatment

Sharmila Upadhya 1,✉, Subramanya Upadhya 2, S Krishna Mohan 1, K Vanajakshamma 1, Mamatha Kunder 1, Seema Mathias 1
PMCID: PMC3454219  PMID: 23105460

Abstract

Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.

Key Words: Glutathione (GSH), Malondialdehyde (MDA), Glutathione S-transferase (GST), Colorectal cancer

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