Abstract
Water extract of dry fruits ofTerminalia chebula (Hindi-Harda, Telugu-Karakkaya) at a dose of 200 mg/kg body weight improved the glucose tolerance as indicated by 44% of reduction in the peak blood glucose at 2nd hour in glucose tolerance test in diabetic (streptozotocin induced) rats. Treatment of diabetic rats with an initial fasting blood glucose of 253±9.4 mg/dl daily once with the water extract (200 mg/kg) for two weeks brought down the fasting blood glucose to 123±8.4 mg/dl which is only slightly above the normal value. These results indicate that water extract of Terminalia chebula improves glucose tolerance and brings down fasting blood glucose in diabetic rats.
Key Words: Terminalia chebula, Diabetes mellitus, Antihyperglycemic effect, Glucose tolerance
Full Text
The Full Text of this article is available as a PDF (173.0 KB).
References
- 1.Sukhla R., Shrma S.B., Prabhu K.M., Murthy P.S. Medicinal plants for treatment of diabetes mellitus. Ind. J. Clin. Biochem. 2000;15:169–177. doi: 10.1007/BF02867556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Indian Council of Medical Research (1976)Medicinal Plants of India, Vol. I.
- 3.Indian Council of Medical Research (1987)Medicinal Plants of India, Vol. II.
- 4.Rossini A.A., Like A.A., Dulin W.E., Cahill G.F. Pancreatic β-cell toxicity by streptozotocin anomers. Diabetes. 1971;26:1120–1124. doi: 10.2337/diabetes.26.12.1120. [DOI] [PubMed] [Google Scholar]
- 5.Babu B.V., Moorti R., Pugazhenthi S., Prabhu K.M., Murthy P.S. Alloxan recovered rabbits as animal model for screening for hypoglycemic activity of compounds. Ind. J. Biochem. Biophys. 1988;25:714–718. [PubMed] [Google Scholar]