Abstract
Even today the ability to provide the patient with clinically adequate pain control with minimum systemic side effects is one of the major concerns all over the world. Lignocaine, the most commonly used local anesthetic agent in oral surgery due to its rapid onset & reasonably good potency, does not have adequate duration of action, unless used with Adrenaline, a drug known for its cardiovascular effects. Centbucridine, a non-ester, non-amide group local anesthetic agent developed in India at C D R I Lucknow, has advantage of inherent vasoconstrictor property. This study was planned to compare 0.5% Centbucridine and 2% Lignocaine with Adrenaline, in exodontia patients. The results were recorded for their efficacy and C V S action and statistically analyzed. Centbucridine was found to be an ideal local anesthetic agent with no effects on cardiovascular parameters and exhibiting a sufficient degree of local anesthetic activity suitable for use in routine minor surgery cases. This will be advantageous where Adrenaline is absolutely contraindicated due to systemic problems.
Keywords: Centbucridine, Lignocaine, Local anaesthetic
Full Text
The Full Text of this article is available as a PDF (60.7 KB).
References
- 1.Patnaik G.K., Rastogi S.N., Anand N., Dhawan B.N. Evaluation of Local anesthetic activity of 4-N-Butylamino-1,2,3,4-Tetrahydroacridine Hydrochloride (Centbucridine)- A 4-Substituted polymethylenequinoline. Indian J Exp Biol. 1982;20(4):327–329. [PubMed] [Google Scholar]
- 2.Centbucridine- A novel anesthetic, summary of data CDRI, New drug no. 3 pp7.
- 3.Patnaik G.K., Dhawan B.N. Pharmacological study of 4 — N Butylamino-1,2,3,4-Tetrahydroacridine Hydrochloride (Centbucridine) — A new local anesthetic. Indian J Exp Biol. 1982;20(4):330–333. [PubMed] [Google Scholar]
- 4.Gupta P.P., Tangri A.N., Saxena R.C., Dhawan B.N. Clinical pharmacological studies on Centbucridine — A new local anesthetic. Indian J Exp Biol. 1982;20(4):344–346. [PubMed] [Google Scholar]
- 5.Nityanand S., Sethi N., Srivastave G. N., Roy A.K., Mukherjee S.K. Chronic Toxicity on Centbucridine- A new local anesthetic. Indian J Exp Biol. 1982;20(4):334–346. [PubMed] [Google Scholar]
- 6.Gupta P.P., Nityanand S., Shipstone A.C., Dhawan B.N. Experimental evaluation of potential neurotoxicity of centbucridine — A new local anesthetic. Indian J Exp Biol. 1982;20(4):339–343. [PubMed] [Google Scholar]
- 7.Sethi N., Mukherjee S.K. Teratogenic studies on Centbucridine, a newer local anesthetic. Indian J Exp Biol. 1982;20(4):337–338. [PubMed] [Google Scholar]
- 8.Gupta P.P., Mishra Y.C., Dhawan B.N. Comparison of centbucridine and lignocaine in dental surgery. Indian J Anaesthesia. 1989;37(3):106–111. [Google Scholar]
- 9.Vacharajani G.N., Parikh N., Paul T., Satoskar R.S. A comparative study of centbucridine and lignocaine in dental extraction. Int J Clin Pharmacol Res. 1983;3(4):251–255. [PubMed] [Google Scholar]