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. 2007 Mar;22(1):29–32. doi: 10.1007/BF02912877

Effect of caffeine on the risk of coronary heart disease— A re-evaluation

J O Adebayo 1,✉, A O Akinyinka 2, G A Odewole 1, J I Okwusidi 1
PMCID: PMC3454246  PMID: 23105648

Abstract

The effect of caffeine intake on the risk of coronary heart disease was studied. Twenty-one rats used were randomly divided into three experimental groups, the first group served as the control while the second and third groups were administered caffeine orally at doses of 10mg/kg body weight and 20mg/kg body weight respectively for fourteen days. Caffeine, at 10mg/kg body weight, significantly increased (P<0.05) serum LDL- cholesterol concentration and coronary heart disease risk ratio while it significantly reduced (P<0.05) serum triacylglycerol concentration when compared with controls. At 20mg/kg body weight, caffeine significantly increased (P<0.05) coronary heart disease risk ratio while it significantly reduced (P<0.05) serum HDL-cholesterol concentration and serum triacylgycerol concentration when compared with controls. No dose response effect was observed possibly suggestive of a threshold effect. These results suggest that caffeine predisposes consumers of caffeine containing beverages to coronary heart disease.

Key words: Caffeine, Coronary heart disease, Blood lipids

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