Abstract
ES materials released along with the release of mf showed immunosuppression as evidenced by a decrease in T lymphocyte levels in the immunised animals. Lipid fractions of the mf associated ES materials and protein fractions of the detergent soluble materials were found to cause suppression of immune response in the host. Further study revealed that the suppression associated with the lipid fractions is actually the end result and that mf associated ES materials is actually a mixture of immunosuppressive and immunopotentiating components and the release of the components is most likely regulated.
Key Words: Setaria digitata, Excretory Secretory materials, Immunopotentiation Immunosuppression
Full Text
The Full Text of this article is available as a PDF (187.2 KB).
References
- 1.Warren K.S., editor. Immunology and Molecular Biology of Parasite infections. 3rd ed. Boston: Black well Publications; 1993. [Google Scholar]
- 2.Sugunan V.S., Kaleysa Raj R. Origin of biologically active materials fromS. digitata. Current Science. 1986;55:331–333. [Google Scholar]
- 3.Dicruse W.S., Kaleysa Raj R. ES materials from different sites of female reproductive tissue of the filarial parasiteS. digitata. Indian J. Exp. Biol. 1988;26:781–783. [PubMed] [Google Scholar]
- 4.Maya Devi C., Kaleysa Raj R. Immune response in mice against hatching associated materials from the filarial parasiteS. digitata. Indian J. Exp. Biol. 1984;32:848–853. [PubMed] [Google Scholar]
- 5.Kaleysa Raj, R., Pradeep, C.G., Rekha, M.R. and Oommen, K.S. Immunomodulation of ES lipids fromS. digitata (under publication).
- 6.John L., Kaleysa Raj R. Immune response of electroeluted detergent soluble surface associated antigens fromS. digitata. Indian J. Exp. Biol. 1997;35:1997–1997. [PubMed] [Google Scholar]