Skip to main content
PMC home page
Journal of Assisted Reproduction and Genetics logoLink to Journal of Assisted Reproduction and Genetics
. 1997 Nov;14(10):575–580. doi: 10.1023/A:1022576500894

Perinatal Outcome of Pregnancies After Assisted Reproduction: A Case–Control Study

M Dhont 1, F De Neubourg 1, J Van der Elst 1, P De Sutter 1
PMCID: PMC3454731  PMID: 9447457

Abstract

Purpose: A matched case–control study of all pregnancies obtained after either IVF or ICSI was conducted to investigate the perinatal outcome.

Methods: Three hundred eleven singleton and 115 twin pregnancies obtained after assisted reproduction were studied. Controls were selected from a regional register and were matched for maternal age, parity, singleton or twin pregnancy, and date of delivery.

Results: No significant difference was observed for gestational age at delivery, birth weight, incidence of congenital anomalies, and incidence of perinatal mortality between ART (singleton and twin) pregnancies and spontaneous controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies (52 vs 42%; P < 0.05) and needed more neonatal intensive care (47 vs 26%; P < 0.05).

Conclusions: From this case–control study it is concluded that the perinatal outcome of ART singleton pregnancies is not different from that in matched controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies and needed more neonatal intensive care.

Keywords: in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), pregnancy, perinatal outcome

Full Text

The Full Text of this article is available as a PDF (523.2 KB).

REFERENCES

  • 1.Lancaster PAL. Australian In Vitro Fertilization Collaborative Group: High incidence of preterm births and early losses in pregnancy after IVF. BMJ. 1985;291:1160–1163. doi: 10.1136/bmj.291.6503.1160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Beral V, Doyle P. MRC Working Party on Children Conceived by In Vitro Fertilisation: Births in Great Britain resulting from assisted conception, 1978–87. BMJ. 1990;300:1229–1233. doi: 10.1136/bmj.300.6734.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Seoud MA, Toner JP, Kruithoff C, Muasher SJ. Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: The Norfolk experience. Fertil Steril. 1992;57:825–834. [PubMed] [Google Scholar]
  • 4.Doyle P, Beral V, Macononchie N. Preterm delivery, low birth weight and small-for-gestational-age in liveborn singleton babies resulting from in-vitro fertilization. Hum Reprod. 1992;7:425–428. doi: 10.1093/oxfordjournals.humrep.a137663. [DOI] [PubMed] [Google Scholar]
  • 5.Tan SL, Doyle P, Campbell S, et al. Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies. Am J Obstet Gynecol. 1992;167:778–784. doi: 10.1016/s0002-9378(11)91589-0. [DOI] [PubMed] [Google Scholar]
  • 6.Olivennes F, Rufat P, André B, Pourade A, Quiros MC, Frydman R. The increased risk of complication observed in singleton pregnancies resulting from in-vitro fertilization (IVF) does not seem to be related to the IVF method itself. Hum Reprod. 1993;8:1297–1300. doi: 10.1093/oxfordjournals.humrep.a138245. [DOI] [PubMed] [Google Scholar]
  • 7.Rufat P, Olivennes F, de Mouzon J, Dehan M, Frydman R: Task force report on the outcome of pregnancies and children conceived by in vitro fertilization, France 1987–1989. Fertil Steril. 1994;61:324–33. [PubMed] [Google Scholar]
  • 8.Wang JX, Clark AM, Kirby CA. The obstetric outcome of singleton pregnancies following in vitro fertilization/gamete intra-fallopian transfer. Hum Reprod. 1994;9:141–146. doi: 10.1093/oxfordjournals.humrep.a138304. [DOI] [PubMed] [Google Scholar]
  • 9.Kessler L, Lancet M, Borenstein R, Steinmetz A. The problem of the older primipara. Obstet Gynecol. 1980;56:165–169. [PubMed] [Google Scholar]
  • 10.Ghazi HA, Spielberger C, Kallen B. Delivery outcome after infertility—a registry study. Fertil Steril. 1991;55:726–732. doi: 10.1016/s0015-0282(16)54238-1. [DOI] [PubMed] [Google Scholar]
  • 11.Williams MA, Goldman MB, Mittendorf R, Monson RR. Subfertility and the risk of low birth weight. Fertil Steril. 1991;56:668–671. doi: 10.1016/s0015-0282(16)54597-x. [DOI] [PubMed] [Google Scholar]
  • 12.Tuck SM, Yudkin PL, Turnbull AC. Pregnancy outcome in elderly primigravidae with an without a history of infertility. Br J Obstet Gynaecol. 1988;95:230–237. doi: 10.1111/j.1471-0528.1988.tb06862.x. [DOI] [PubMed] [Google Scholar]
  • 13.Li TC, Macleod I, Singhal V, Duncan SLB. The obstetric and neonatal outcome of pregnancy in women with a previous history of infertility: A prospective study. Br J Obstet Gynaecol. 1991;98:1087–1092. doi: 10.1111/j.1471-0528.1991.tb15359.x. [DOI] [PubMed] [Google Scholar]
  • 14.Petersen K, Hornnes PJ, Ellingsen S, Jensen F, Brocks V, Starup J, Ramsøe Jacobsen J, Nyboe Andersen A. Perinatal outcome after in vitro fertilization. Acta Obstet Gynecol Scand. 1995;74:129–131. doi: 10.3109/00016349509008921. [DOI] [PubMed] [Google Scholar]
  • 15.Bonduelle M, Legein J, Buysse A, Van Assche E, Wisanto A, Devroey P, Van Steirteghem A, Liebaers I. Prospective follow-up study of 423 children born after intracytoplasmic sperm injection. Hum Reprod. 1996;11:1558–1564. doi: 10.1093/oxfordjournals.humrep.a019437. [DOI] [PubMed] [Google Scholar]
  • 16.Bonduelle M, Wilikens A, Buysse A, Devroey P, Van Steirteghem A, Liebaers I. Een follow-up-studie van kinderen geboren na intracytoplasmatische sperma-injectie. Tijdschrift Fertiliteitsonderzoek. 1997;11:13–19. [Google Scholar]
  • 17.In 't Veld P, Brandenburg H, Verhoeff A, Dhont M, Los F: Sex chromosomal abnormalities and intracytoplasmic sperm injection. Lancet. 1995;346:773. doi: 10.1016/s0140-6736(95)91531-1. [DOI] [PubMed] [Google Scholar]
  • 18.Van Opstal D, Los FJ, Ramlakhan S, Van Hemel JO, Van Den Ouweland AMW, Brandenburg H, Pieters MHEC, Verhoeff A, Vermeer MCS, Dhont M, In 't Veld PA. Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection. Hum Reprod. 1997;12:682–686. doi: 10.1093/humrep/12.4.682. [DOI] [PubMed] [Google Scholar]
  • 19.Bonduelle M, Legein J, Derde MP, Buysse A, Schietecatte J, Wisanto A, Devroey P, Van Steirteghem A, Liebaers I. Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization. Hum Reprod. 1995;10:3327–3331. doi: 10.1093/oxfordjournals.humrep.a135914. [DOI] [PubMed] [Google Scholar]
  • 20.De Neubourg F, Van Mullem A, Van der Elst J, Defoort P, De Sutter P, Dhont M: Comparative study of the perinatal outcome of 325 children born after in-vitro fertilization and 429 children born after intracytoplasmic sperm injection. 13th Annual Meeting of the European Society of Human Reproduction and Embryology. Edinburgh, United Kingdom, 22–25 June 1997. Hum Reprod 12, Abstract Book 1, Abstract 0–125
  • 21.Verlaenen H, Cammu H, Derde MP, Amy JJ. Singleton pregnancy after in-vitro fertilization: Expectations and outcome. Obstet Gynecol. 1995;86:906–910. doi: 10.1016/0029-7844(95)00322-I. [DOI] [PubMed] [Google Scholar]
  • 22.Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning RV ., Jr Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr. 1995;127:794–800. doi: 10.1016/s0022-3476(95)70175-3. [DOI] [PubMed] [Google Scholar]
  • 23.Tanbo T, Dale PO, Lunde O, Moe N, Abyholm T. Obstetric outcome in singleton pregnancies after assisted reproduction. Obstet Gynecol. 1995;86:188–192. doi: 10.1016/0029-7844(95)00159-o. [DOI] [PubMed] [Google Scholar]
  • 24.Bernasko J, Lynch L, Lapinski R, Berkowitz RL. Twin pregnancies conceived by assisted reproductive techniques: Maternal and neonatal outcomes. Obstet Gynecol. 1997;89:368–372. doi: 10.1016/S0029-7844(96)00527-3. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Assisted Reproduction and Genetics are provided here courtesy of Springer Science+Business Media, LLC

RESOURCES