Abstract
Purpose:The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer.
Methods:Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the β-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates.
Results:The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively.
Conclusions:No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
Keywords: aspirin, endometrial architecture, frozen embryos, pregnancy, transvaginal sonography
Full Text
The Full Text of this article is available as a PDF (363.9 KB).
REFERENCES
- 1.Sher G, Feinman M, Zouves C, Kuttner G, Maassarani G, Salem R, Matzner W, Ching W, Chong P. High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Hum Reprod. 1994;9:2278–2283. doi: 10.1093/oxfordjournals.humrep.a138437. [DOI] [PubMed] [Google Scholar]
- 2.Schenk LM, Butler L, Monis JP, Cox B, Leete J, Abuhamed A, Oehninger S, Muasher S: Heparin and aspirin treatment yields higher implantation rates in IVF patients with antiphospholipid antibody seropositivity compared to untreated seronegative patients. Fifty-Second Annual Meeting of the American Society for Reproductive Medicine, Nov 2-6, 1996
- 3.Kutteh WH, Yetman DL, Chantilis SJ, Byrd W, Crain J, Murty GS: Increased occurrence of early pregnancy loss associated with the presence of anticardiolipin antibodies (ACA) in women undergoing IVF. Fifty-Second Annual Meeting of the American Society for Reproductive Medicine, Nov 2-6, 1996
- 4.Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR. The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod. 1994;9:1954–1957. doi: 10.1093/oxfordjournals.humrep.a138366. [DOI] [PubMed] [Google Scholar]
- 5.Baker AF, Check JH, Hourani CL: Survival and pregnancy rates of pronuclear stage human embryos cryopreserved and thawed using a single step addition and removal of cryoprotectant. Hum Reprod Update 2 (CD-ROM), item 12
- 6.Check JH, Hoover L, Nazari A, O'Shaughnessy A, Summers D. The effect of assisted hatching on pregnancy rates after frozen embryo transfer. Fertil Steril. 1996;65:254–257. doi: 10.1016/s0015-0282(16)58080-7. [DOI] [PubMed] [Google Scholar]
- 7.Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J. Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril. 1997;68:927–930. doi: 10.1016/s0015-0282(97)00330-0. [DOI] [PubMed] [Google Scholar]
- 8.Check JH, Nowroozi K, Choe J, Dietterich C. Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization. Fertil Steril. 1991;56:1173–1175. doi: 10.1016/s0015-0282(16)54736-0. [DOI] [PubMed] [Google Scholar]
- 9.Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C. The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril. 1993;59:72–75. doi: 10.1016/s0015-0282(16)55617-9. [DOI] [PubMed] [Google Scholar]