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. 1998 Sep;15(8):469–477. doi: 10.1023/A:1022578303272

Preservation of Fertility in Women Undergoing Chemotherapy: Current Approach and Future Prospects

Ronit Abir 1,✉, Benjamin Fisch 1, Ahud Raz 1, Shmuel Nitke 1, Zion Ben-Rafael 1
PMCID: PMC3455041  PMID: 9785194

Abstract

Purpose:Anticancer treatment causes ovarian failure.

Methods:Some hormones may have a protective effect on the ovary. Cryopreservation (freezing) of oocytes has had very limited success, and therefore, currently its use before chemotherapy is not a feasible option. However, cryopreservation of embryos is possible. Another solution is oocyte donation followed by in vitro fertilization (IVF).

Results:Ovarian cortical slices containing primordial follicles have been cryopreserved successfully. To restore fertility, cryopreserved–thawed tissue taken from cancer patients before therapy could be replanted after recovery. The possible risk of malignancy restoration could be eliminated by obtaining unilaminar follicles from cryopreserved–thawed tissue and growing them in vitro, followed by routine IVF.

Conclusions:Although women who undergo chemotherapy face limited options for fertility preservation, intensive studies in cryopreservation and in vitro maturation of follicles harbor hope for brighter prospects in the future.

Keywords: primordial follicles, chemotherapy, “protective” hormonal treatment, cryopreservation, in vitro maturation

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