Characterization of cancellous bone architecture by μCT analysis during LT treatment. Analysis shown was performed in lumbar vertebrae. A. Loss of cancellous bone in WT mice in BV/TV, Tb.N. and Tb.Sp. (n = 12–19). B. AR2.3-tg mice show the same cancellous bone loss even after DHT treatment (n = 12). C. Cancellous bone loss in AR3.6-tg mice (n = 9–12). All data expressed as mean ± SEM. ** p < 0.01, *** p < 0.001 vs. sham controls; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. ORX; + p < 0.05, ++ p < 0.01, +++ p < 0.001 vs. WT sham.