Abstract
Purpose: To determine if seasonal changes alter pregnancy rate in intrauterine insemination (IUI) patients.
Methods: One-thousand and eighty semen analyses prepared for IUI were evaluated in this retrospective cohort study of 496 patients.
Results: Volume, pH, sperm concentration, and pregnancy rates were not altered by season. However, the percent motility, the total motile spermatozoa in the ejaculate, the straight-line velocity (VSL) of spermatozoa, as well as the morphology of sperm were altered by season. In a subset of these patients that were defined as normal, only the VSL and the morphology of the spermatozoa were altered by seasonal changes.
Conclusions: Seasonality alters sperm motility parameters as well as morphology, but these changes are not significant enough to alter pregnancy rates.
Keywords: Intrauterine insemination, seasonality, semen parameters
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REFERENCES
- 1.Kerin JFP, Peek J, Warnes GM, Kirby C, Jeffrey R, Matthews CD, Cox LW. Improved conception rate after in-trauterine insemination of washed spermatozoa from men with poor quality semen. Lancet. 1984;10:533–536. doi: 10.1016/s0140-6736(84)90932-2. [DOI] [PubMed] [Google Scholar]
- 2.Allen NC, Herbert CM, Maxson WS, Rogers BJ, Diamond MP, Wentz AC. Intrauterine insemination: A critical review. Fertil Steril. 1985;44:569–580. doi: 10.1016/s0015-0282(16)48969-7. [DOI] [PubMed] [Google Scholar]
- 3.Campana A, Sakkas D, Stalberg A, Bianchi PG, Comte I, Pache T, Walker D. Intrauterine insemination: Evalution of the results according to the woman's age, sperm quality, to-tal sperm count per insemination and life table analysis. Hum Reprod. 1996;11:732–736. doi: 10.1093/oxfordjournals.humrep.a019244. [DOI] [PubMed] [Google Scholar]
- 4.Nuojua-Huttunen S, Tomas C, Bloigu R, Tuomivaara L, Martikainen H. Intrauterine insemination treatment in subfer-tility: An analysis of factors affecting outcome. Hum Reprod. 1999;14:698–703. doi: 10.1093/humrep/14.3.698. [DOI] [PubMed] [Google Scholar]
- 5.Vincent CK. Effects of season and high environmental temper-ature on fertility in cattle: A review. JAVMA. 1972;161:1333–1338. [PubMed] [Google Scholar]
- 6.Gordis L. Epidemiology. Philadelphia: W.B. Saunders; 1996. pp. 118–119. [Google Scholar]
- 7.Johnson JE, Boone WR, Blackhurst DW: Manual versus computer-automated semen analyses: Part I. Comparison of counting chambers. Fertil. Steril 1996;65:150–155 [DOI] [PubMed]
- 8.Davis RO, Katz DF. Standardization and comparability of CASA instruments. J Androl. 1992;13:81–86. [PubMed] [Google Scholar]
- 9.Ginsburg KA, Aramant DR. The influence of chamber charac-teristics on the reliability of sperm concentration and move-ment measurements obtained by manual and videomicro-graphic analysis. Fertil Steril. 1990;53:882–887. doi: 10.1016/s0015-0282(16)53526-2. [DOI] [PubMed] [Google Scholar]
- 10.Levine RJ, Mathew RM, Chenault CB, Brown MH, Hurtt ME, Bentley KS, Mohr KL, Working PK. Differences in the quality of semen in outdoor workers during summer and winter. N Engl J Med. 1990;323:12–16. doi: 10.1056/NEJM199007053230103. [DOI] [PubMed] [Google Scholar]
- 11.Levine RJ, Brown MH, Bell M, Shue F, Greenberg GN, Bordson BL. Air-conditioned environments do not prevent Steril. 1992;57:1075–1083. doi: 10.1016/s0015-0282(16)55027-4. [DOI] [PubMed] [Google Scholar]
- 12.Rojansky N, Brzezinski A, Schenker JG. Seasonality in hu-man reproduction: An update Hum Reprod. 1992;7:735–745. doi: 10.1093/oxfordjournals.humrep.a137729. [DOI] [PubMed] [Google Scholar]
- 13.Centola GM, Eberly S. Seasonal variations and age-related changes in human sperm count, motility, motion parameters, morphology, and white blood cell concentration. Fertil Steril. 1999;72:803–808. doi: 10.1016/s0015-0282(99)00395-7. [DOI] [PubMed] [Google Scholar]
- 14.Baker HWG, Burger HG, de Krester DM, Lording DW, McGowan P, Rennie GC. Factors affecting the variability of se-men analysis results in infertile men. Int J Androl. 1981;4:609–622. doi: 10.1111/j.1365-2605.1981.tb00743.x. [DOI] [PubMed] [Google Scholar]
- 15.Chen Z, Toth T, Godfrey-Bailey L, Mercedat N, Schiff I, Hauser R. Seasonal variation and age-related changes in hu-man semen parameters. J Androl. 2003;24:226–231. doi: 10.1002/j.1939-4640.2003.tb02666.x. [DOI] [PubMed] [Google Scholar]
- 16.Andolz P, Bielsa MA, Andolz A. Circannual variation in human semen parameters. Int J Androl. 2001;24:266–271. doi: 10.1046/j.1365-2605.2001.00297.x. [DOI] [PubMed] [Google Scholar]
- 17.Sharpe RM. Lifestyle and environmental contribution to male infertility. Br Med Bull. 2000;56:630–642. doi: 10.1258/0007142001903436. [DOI] [PubMed] [Google Scholar]
- 18.Aleandri V, Spina V, Morini A. The pineal gland and reproduc-tion. Hum Reprod. 1996;2:225–235. doi: 10.1093/humupd/2.3.225. [DOI] [PubMed] [Google Scholar]
- 19.Silman R. Melatonin and the human gonadotrophin-releasing hormone pulse generator. J Endocrinol. 1991;128:7–11. doi: 10.1677/joe.0.1280007. [DOI] [PubMed] [Google Scholar]
- 20.Partonen T. Short note: Melatonin-dependent infertility. Med Hypotheses. 1999;52:487–488. doi: 10.1054/mehy.1998.0629. [DOI] [PubMed] [Google Scholar]
- 21.Sharpe RM, Franks S. Environment, lifestyle, and infertility—An inter-generational issue. Nat Cell Biol. 2002;4(Suppl.1):S33–S40. doi: 10.1038/ncb-nm-fertilityS33. [DOI] [PubMed] [Google Scholar]
- 22.Ong C, Shen H, Chia S. Biomarkers for male reproductive health hazards: Are they available? Toxicol Lett. 2002;134:17–30. doi: 10.1016/s0378-4274(02)00159-5. [DOI] [PubMed] [Google Scholar]