Abstract
Purpose: To identify characteristics of female patients andof semen that were associated with live birth followingintra-uterine insemination (IUI).
Methods: Retrospective review of medical and laboratoryresults from 533 women who underwent IUI with partner'ssperm from 1993 through 1995.
Results: Among 1728 cycles, 116 (6.7%) resulted in livedeliveries. Among the 38 patient and semen variablesanalyzed, only 3 were associated with successful IUI outcome:female age <37.7 years at the time of treatment (P = 0.02);the absence of any corrective pelvic surgery (P < 0.001);and postwash sperm motility (P = 0.006). Couples withnone of these three risk factors achieved per-cycle pregnancyrates of 12.4%. Women with two risk factors (age and pelvicsurgery) achieved per-cycle pregnancy rates of 4.6% whensperm had good postwash motility. No pregnancies wereachieved when low postwash motility was combined withany other risk factor.
Conclusions: Advanced female age, poor postwash spermmotility, and a history of corrective pelvic surgery aresignificant risk factors for poor IUI success rates. Poor postwashsperm motility in combination with either of these other tworisk factors resulted in no successful pregnancies.
Keywords: infertility—male, infertility—female, insemination—martificial, sperm motility, pregnancy rate
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