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. 2001 Dec;18(12):655–659. doi: 10.1023/A:1013115301159

The Effect of Single-Dose Oxytocin Application on Time to Ejaculation and Seminal Parameters in Men

Katharina Walch 1, Ruth Eder 1, Andreas Schindler 2, Wilfried Feichtinger 1
PMCID: PMC3455247  PMID: 11808847

Abstract

Purpose: To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters.

Methods: The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVF patients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prior oxytocin treatment.

Results: No significant difference was noted between the two groups concerning ejaculation time and semen parameters.

Conclusions: Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.

Keywords: ejaculation, masturbation, oxytocin, seminal parameters, sperm output

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REFERENCES

  • 1.Bruins J, Hijman R, Van Ree JM. Effect of a single dose of Des-Glycinamide-(Arg8)vasopressin or oxytocin on cognitive processes in young healthy subjects. Peptides. 1992;133:461–468. doi: 10.1016/0196-9781(92)90075-e. [DOI] [PubMed] [Google Scholar]
  • 2.Pitman RK, Orr SP, Lasko B. Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res. 1993;48:107–117. doi: 10.1016/0165-1781(93)90035-f. [DOI] [PubMed] [Google Scholar]
  • 3.Pedersen CA, Ascher YL, Monroe YL, Prange AJ. Oxytocin induces maternal behaviour in vergin female rats. Science. 1982;216:648. doi: 10.1126/science.7071605. [DOI] [PubMed] [Google Scholar]
  • 4.Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K. Oxytocin and sexual behaviour in the male rat and rabbit. J. Endocrinol. 1995;107(1):97–106. doi: 10.1677/joe.0.1070097. [DOI] [PubMed] [Google Scholar]
  • 5.Arletti R, Benelli A, Bertolini A. Sexual behaviour of aging male rats is stimulated by oxytocin. Eur J Pharmacol. 1990;179(3):377–381. doi: 10.1016/0014-2999(90)90178-9. [DOI] [PubMed] [Google Scholar]
  • 6.Fjellström D, Kihlström JE, Melin P. The effect of synthetic oxytocin upon seminal characteristics and sexual behaviour in male rabbits. J Reprod Fertil. 1968;17:207–209. doi: 10.1530/jrf.0.0170207. [DOI] [PubMed] [Google Scholar]
  • 7.Murphy MR, Seckl JR, Burton S, Checkley SA, Lightman SL. Changes in oxytocin and vasopressin secretion during sexual activity in men. J Clin Endocrinol Metab. 1987;65:738–741. doi: 10.1210/jcem-65-4-738. [DOI] [PubMed] [Google Scholar]
  • 8.Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987;641:27–31. doi: 10.1210/jcem-64-1-27. [DOI] [PubMed] [Google Scholar]
  • 9.Ivell R, Balvers M, Rust W, Bathgate R, Einspanier A. Oxytocin and male reproductive function. Adv Exp Med Biol. 1997;424:253–264. doi: 10.1007/978-1-4615-5913-9_47. [DOI] [PubMed] [Google Scholar]
  • 10.Argiolas A, Collu M, Gessa GL, Melis MR, Serra G. The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats. Eur J Pharmacol. 1988;149:389–392. doi: 10.1016/0014-2999(88)90675-9. [DOI] [PubMed] [Google Scholar]
  • 11.Harris GC, Nicholson HD. Stage-related differences in rat seminiferous tubule contractility in vitro and their response to Oxytocin. J Endocrinol. 1998;157:251–257. doi: 10.1677/joe.0.1570251. [DOI] [PubMed] [Google Scholar]
  • 12.Spiteri-Grech J, Nieschlag E. Paracrine factors relevant to the regulation of spermatogenesis-A review. J Reprod Fertil. 1993;98:1–14. doi: 10.1530/jrf.0.0980001. [DOI] [PubMed] [Google Scholar]
  • 13.Ohanian C, Rodriguez H, Piriz H, Martino I, Rieppi G, Garofalo EG, Roca RA. Studies on the activity and ultrastructure of the boar testicular capsule. J Reprod Fertil. 1979;57:79–85. doi: 10.1530/jrf.0.0570079. [DOI] [PubMed] [Google Scholar]
  • 14.Sharma OP, Hays RL. A possible role for oxytocin in sperm transport in the male rabbit. J Endocrinol. 1976;68(1):43–47. doi: 10.1677/joe.0.0680043. [DOI] [PubMed] [Google Scholar]
  • 15.Nicholson HD, Worley RTS, Guldenaar SEF, Pickering BT. Ethan-1,2-dimethanesulphonate reduces testicular oxytocin and seminiferous tubule movements in the rat. J Endocrinol. 1987;1122:311–316. doi: 10.1677/joe.0.1120311. [DOI] [PubMed] [Google Scholar]
  • 16.Voglmayr JK. Output of spermatozoa and fluid by the testis of the ram and ist response to oxytocin. J Reprod Fertil. 1975;431:119–122. doi: 10.1530/jrf.0.0430119. [DOI] [PubMed] [Google Scholar]
  • 17.Agmo AJ. Neurohypophysial hormones and the emission of semen in rabbits. J Reprod Fertil. 1975;45(2):243–248. doi: 10.1530/jrf.0.0450243. [DOI] [PubMed] [Google Scholar]
  • 18.Da Silva e Souza MC, Gimeno MF, Gimeno AL. Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis. Fertil Steril. 1975;2612:1250–1256. doi: 10.1016/s0015-0282(16)41542-6. [DOI] [PubMed] [Google Scholar]
  • 19.Nicholson HD, Parkinson TJ, Lapwood KR. Effects of oxytocin and vasopressin on sperm transport from the cauda epididymis in sheep. J Reprod Fertil. 1999;117(2):299–305. doi: 10.1530/jrf.0.1170299. [DOI] [PubMed] [Google Scholar]
  • 20.Veeramachaneni DN, Amann RP. Oxytocin in the ovine ductuli efferentes and caput epididymidis: Immunolocalization and endocytosis from the luminal fluid. Endocrinology. 1990;126:1156–1164. doi: 10.1210/endo-126-2-1156. [DOI] [PubMed] [Google Scholar]
  • 21.Nicholson HD, Guldenaar SEF, Boer GJ, Pickering BT. Testicular oxytocin: Effects of intratesticular oxytocin in the rats. J Endocrinol. 1991;130:231–238. doi: 10.1677/joe.0.1300231. [DOI] [PubMed] [Google Scholar]
  • 22.Silvia WJ, Brockman JA, Kaminski MA, DeWitt DL, Smith WL. Prostaglandin endoperoxide synthase in seminal vesicle. Molecul Androl. 1994;6:197–207. [Google Scholar]
  • 23.Argiolas A, Melis MR, Gessa GL. Oxytocin: An extremely potent inducer of penile erection and yawning in male rats. Eur J Pharmacol. 1986;130:265–272. doi: 10.1016/0014-2999(86)90277-3. [DOI] [PubMed] [Google Scholar]
  • 24.Melis MR, Mauri A, Argiolas A. Apomrphine-and oxytocin-induced penile erection and yawning in intact and castrated male rats: Effects of sexual steriods. Neuroendocrinology. 1994;59(4):349–354. doi: 10.1159/000126677. [DOI] [PubMed] [Google Scholar]
  • 25.Argiolas A. Nitric oxide is a central mediator of penile erection. Neuropharmacology. 1994;33(11):1339–1344. doi: 10.1016/0028-3908(94)90034-5. [DOI] [PubMed] [Google Scholar]
  • 26.Argiolas A, Melis MR, Vargiu L, Gessa GL. d(CH2)5Tyr (Me)2-(Orn8)vasotocin, a potent oxytocin antagonist, antagonizes penile erection and yawning induced by oxytocin and apomorphine, but not by ACTH-(1-24) Eur J Pharmacol. 1987;134:221–224. doi: 10.1016/0014-2999(87)90168-3. [DOI] [PubMed] [Google Scholar]
  • 27.Melis MR, Spano MS, Succu S, Argiolas A. The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci Lett. 1999;265:171–174. doi: 10.1016/s0304-3940(99)00236-0. [DOI] [PubMed] [Google Scholar]
  • 28.Berndtson WE, Igboeli G. Spermatogenesis, sperm output and seminal quality of Holstein bulls electroejaculated after administration of oxytocin. J Reprod Fertil. 1988;82(2):467–475. doi: 10.1530/jrf.0.0820467. [DOI] [PubMed] [Google Scholar]
  • 29.Zavos PM. Seminal parameters of ejaculates collected from oligospermic and normospermic patients via masturbation and at intercourse with the use of a Silatic seminal fluid collection device. Fertil Steril. 1985;44:517–520. doi: 10.1016/s0015-0282(16)48923-5. [DOI] [PubMed] [Google Scholar]
  • 30.Zavos PM, Kofinas GD, Sofikitis NS, Zarmakoupis PN, Miyagawa I. Differences in seminal parameters in specimens collected via intercourse and incomplete intercourse (coitus interruptus) Fertil Steril. 1994;61(6):1174–1176. doi: 10.1016/s0015-0282(16)56779-x. [DOI] [PubMed] [Google Scholar]
  • 31.van Roijen JH, Slob AK, Gianotten WL, Dohle GR, van der Zon ATM, Vreeburg JTM, Weber RFA. Sexual arousal and the quality of semen produced by masturbation. Human Reprod. 1996;111:147–151. doi: 10.1093/oxfordjournals.humrep.a019008. [DOI] [PubMed] [Google Scholar]
  • 32.Powers RP, Derrick FC, Jonsson HT. Lack of oxytocin effect on sperm output in oligospermic males. Urology. 1982;19(5):523–524. doi: 10.1016/0090-4295(82)90610-0. [DOI] [PubMed] [Google Scholar]
  • 33.Goverde HJM, Bisserling JGA, Witzels AMM, Braat DDM. A neuropeptide in human semen: Oxytocin. Arch Androl. 1998;41:17–22. doi: 10.3109/01485019808988540. [DOI] [PubMed] [Google Scholar]
  • 34.Lidberg L, Sternthal V. A new approach to the treatment of impotentia erectionis. Pharmakopsychiatry. 1977;10(1):21–25. doi: 10.1055/s-0028-1094514. [DOI] [PubMed] [Google Scholar]
  • 35.Cantor JM, Binik YM, Pfaus JG. Chronic fluoxetine inhibits sexual behaviour in the male rat: Reversal with oxytocin. Psychopharmacology. 1999;144:355–362. doi: 10.1007/s002130051018. [DOI] [PubMed] [Google Scholar]

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