Abstract
Purpose: To examine the roles of Interleukin-1 (IL-1) and IL-1 receptor antagonist (IL-1ra), in in vitro embryo development and subsequent pregnancy outcome.
Methods: Maternal serum utilized to supplement embryo growth in IVF cycles was analyzed for the presence of IL-1 cytokines.
Results: The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL-1β and IL-1ra.
Conclusions: Relative antagonism of the IL-1 system was positively associated with embryo development and pregnancy outcome.
Keywords: Embryo, endometrium, interleukin-1, interleukin-1 receptor antagonist, IVF
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