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Journal of Assisted Reproduction and Genetics logoLink to Journal of Assisted Reproduction and Genetics
. 2000 Nov;17(10):586–590. doi: 10.1023/A:1026491426423

Low-Dose Aspirin Does Not Increase Implantation Rates in Patients Undergoing Intracytoplasmic Sperm Injection: A Prospective Randomized Study

Bulent Urman 1, Ramazan Mercan 1, Cengiz Alatas 1, Basak Balaban 1, Aycan Isiklar 1, Alp Nuhoglu 1
PMCID: PMC3455451  PMID: 11209540

Abstract

Purpose: The aim was to evaluate the effect of aspirin on pregnancy and implantation rates in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI).

Methods: Two hundred and seventy-nine patients were randomized to receive 80 mg of aspirin (n = 139) or no treatment (r = 136) starting from the first day of controlled ovarian hyperstimulation.

Results: Duration of stimulation, gonadotropin consumption, peak estradiol, number of oocytes retrieved, fertilization rate, cleavage rate, and number of embryos transferred were similar in the two groups. Implantation and clinical pregnancy rates were 15.6% and 39.6% versus 15.1% and 43.4% in aspirin treated and untreated groups, respectively (P > 0.05).

Conclusions: Low-dose aspirin administration does not improve implantation and pregnancy rates in an unselected group of patients undergoing ICSI.

Keywords: aspirin, assisted reproduction, pregnancy

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