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. 1997 Jul;20(3):141–149. doi: 10.1007/s11357-997-0013-1

Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress

M T Droy-Lefaix 1
PMCID: PMC3455891  PMID: 23604306

Abstract

Aging is responsible for oxidative damage to DNA, protein, lipid, and other macromolecules linked to tissue alterations. The resultant damage contributes significantly to degenerative diseases, to include those of the brain, sensorial tissues, and cardiovascular system. To protect cellular components from oxyradical attack, especially lipoperoxidation, a substantial interest in the use of antioxidants has evolved. A free radical scavenger, Ginkgo biloba extract (EGb 761) may be effective in fighting the oxidative stress related to aging. Many data support the efficacy of EGb 761 in biological model systems. In aging processes, EGb 761 may ameliorate the mitochondria respiratory chain function by quenching the superoxide anion, and the hydroxyl and peroxyl radicals. It protects the brain by facilitating the uptake of neurotransmitters and by reducing ischemia-reperfusion episodes and level of apoptosis. Moreover, in sensorial tissues, EGb 761 reduces apoptosis in the olfactive bulb and in the retinal pigmented epithelium of the eye, and protects against the lipoperoxidation alteration of the retina that results in a decrease of the electroretinogram response. In the cardiovascular system, by a direct effect on oxidative low density lipoproteins, EGb 761 may decrease atherosclerosis evolution, and is shown to accelerate cardiac mechanical recovery after ischemia-reperfusion. In conclusion, the antioxidant effects of EGb 761 noted in many experimental data, may explain the therapeutic efficacy observed in clinical trials of the elderly. These beneficial properties seem in part to come from the activity of EGb 761 constituents, such as flavonoids and terpens.

Key words: Ginkgo biloba extract, Antioxidants, Oxidative stress, Aging

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References

  • 1.Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. 1993;90:7915–7922. doi: 10.1073/pnas.90.17.7915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.de Groot H. Reactive oxygen species in tissue injury. Hepato-Gastroenterol. 1994;41:328–332. [PubMed] [Google Scholar]
  • 3.Dianzani M.V. Free radicals in physiology and pathology. Boll. Soc. It. Biol. Sper. 1992;LXVIII:491–511. [PubMed] [Google Scholar]
  • 4.Zimmerman J.J. Oxyradical pathophysiology. Adv. Pediat. 1995;42:243–302. [PubMed] [Google Scholar]
  • 5.Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 1992;59:1609–1623. doi: 10.1111/j.1471-4159.1992.tb10990.x. [DOI] [PubMed] [Google Scholar]
  • 6.Barber D.A., Harris S.R. Oxygen free radicals and antioxidants: a review. Amer. Pharm. 1994;NS34:26–35. doi: 10.1016/s0160-3450(15)30310-x. [DOI] [PubMed] [Google Scholar]
  • 7.Beyer R.E. The role of ascorbate in antioxidant protection of biomembranes: interaction with vitamin E and coenzyme Q. J. Bioenerg. Biomembrane. 1994;26:349–358. doi: 10.1007/BF00762775. [DOI] [PubMed] [Google Scholar]
  • 8.Halliwell B. Free radicals, antioxidants and human disease: curiosity, cause, or consequence? Lancet. 1994;344:721–724. doi: 10.1016/S0140-6736(94)92211-X. [DOI] [PubMed] [Google Scholar]
  • 9.Landvik S.V., Diplock A.J., Packer L. Efficacy of vitamin E in human health and disease. In: Cadenas H., Packer L., editors. Handbook of Antioxidants. New York: Marcel Dekker Inc.; 1996. pp. 63–87. [Google Scholar]
  • 10.Barja de Quiroga G., Lopez-Torres M., Perez-Campo R. Relationship between antioxidants, lipid peroxidation and aging. In: Emerit I., Chance B., editors. Free Radicals and Aging. Basel: Birkhäuser Verlag; 1992. pp. 109–123. [DOI] [PubMed] [Google Scholar]
  • 11.Michel, P.F.: Ginkgo biloba: l’arbre qui a vaincu le temps. Paris, Editions du Félin, 1986.
  • 12.Chang H.M., But P.P.H. Pharmacology and applications of Chinese materia medica. Singapore: World Scientific Publ. Co; 1987. pp. 1096–1101. [Google Scholar]
  • 13.DeFeudis F.V. Ginkgo biloba extract (EGb 761): Pharmacological activities and clinical applications. Paris: Elsevier; 1991. [Google Scholar]
  • 14.Kleijnen J., Knipschild P. Ginkgo biloba. Lancet. 1992;340:1136–1139. doi: 10.1016/0140-6736(92)93158-J. [DOI] [PubMed] [Google Scholar]
  • 15.Droy-Lefaix M.T., Baudouin C., de Kozak Y., Doly M. Free radicals and antioxidants in pathophysiology of mammalian retina. In: Packer P., Hiramatsu M., Yoshikawa T., editors. Free Radicals in Brain Physiology and Disorders. San Diego: Academic Press; 1996. pp. 359–367. [Google Scholar]
  • 16.Haramaki N., Packer L., Droy-Lefaix M.T., Christen Y. Antioxidant actions and health implications of Ginkg biloba extract. In: Cadenas E., Packer L., editors. Handbook of Antioxidants. New York: Marcel Dekker Inc.; 1996. pp. 487–510. [Google Scholar]
  • 17.Vanhaelen M., Vanhaelen-Fastré R. Countercurrent chromatography for isolation of flavonol glycosides from Ginkgo biloba leaves. J. Liq. Chromatogr. 1988;11:2969–2975. [Google Scholar]
  • 18.Halliwell B., Gutteridge J.M.C. Free radicals in biology and medicine. Oxford: Clarendon Press; 1989. [Google Scholar]
  • 19.Gardès-Albert M., Ferradini C., Sekaki A., Droy-Lefaix M.T. Oxygen-centered free radicals and their interaction with EGb 761 or CP202. In: Ferradini C., Droy-Lefaix M.T., Christen Y., editors. Advances in Ginkgo biloba extract research, Vol. 2, Ginkgo biloba extract (EGb 761) as a free-radical scavenger. Paris: Elsevier; 1993. pp. 1–11. [Google Scholar]
  • 20.Marcocci L., Packer L., Droy-Lefaix M.T., Sekaki A.H., Gardès-Albert M. Antioxidant action of Ginkgo biloba extract EGb 761. In: Packer L., editor. Methods in Enzymology. San Diego: Academic Press; 1994. pp. 462–475. [DOI] [PubMed] [Google Scholar]
  • 21.Pincemail J., Deby C. Propriétés antiradicalaires de l’extrait de Ginkgo biloba. Presse Méd. 1986;15:1475–1479. [PubMed] [Google Scholar]
  • 22.Robak J., Gryglewski R.J. Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 1988;37:837–841. doi: 10.1016/0006-2952(88)90169-4. [DOI] [PubMed] [Google Scholar]
  • 23.Husain S.R., Cillard J., Cillard P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry. 1987;26:2489–2491. doi: 10.1016/S0031-9422(00)83860-1. [DOI] [Google Scholar]
  • 24.Bors W., Heller W., Michel C., Saran M. Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol. 1990;189:343–355. doi: 10.1016/0076-6879(90)86128-I. [DOI] [PubMed] [Google Scholar]
  • 25.Sichel G., Corsaro C., Scalia M., Di Bilio A.G., Bonomo R.P. In vitro scavenger activity of some flavonoids and melamino against O2.- Free Rad. Biol. Med. 1991;11:1–8. doi: 10.1016/0891-5849(91)90181-2. [DOI] [PubMed] [Google Scholar]
  • 26.Dumont E., Petit E., Tarrade T., Nouvelot A. UV-C irradiation-induced peroxidative degradation of microsomal fatty acid and proteins: protection by an extract of Ginkgo biloba (EGb 761) Free Rad. Biol. Med. 1992;13:197–203. doi: 10.1016/0891-5849(92)90015-9. [DOI] [PubMed] [Google Scholar]
  • 27.Maitra I., Marcocci L., Droy-Lefaix M.T., Packer L. Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761. Biochem. Pharmacol. 1995;49:1649–1665. doi: 10.1016/0006-2952(95)00089-I. [DOI] [PubMed] [Google Scholar]
  • 28.Yuting C., Rongliang Z., Zhongjian J., Yong J. Flavonoids as superoxide scavengers and antioxidants. Free Rad. Biol. Med. 1990;9:19–21. doi: 10.1016/0891-5849(90)90045-K. [DOI] [PubMed] [Google Scholar]
  • 29.Marcocci L., Maguire J.J., Droy-Lefaix M.T., Packer L. The nitric oxide-scavenging properties of Ginkgo biloba extract, EGb 761. Biochem. Biophys. Res. Comm. 1994;201:748–755. doi: 10.1006/bbrc.1994.1764. [DOI] [PubMed] [Google Scholar]
  • 30.Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956;11:298–300. doi: 10.1093/geronj/11.3.298. [DOI] [PubMed] [Google Scholar]
  • 31.Benzi G., Moretti A. Age-and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Rad. Biol. Med. 1995;19:77–101. doi: 10.1016/0891-5849(94)00244-E. [DOI] [PubMed] [Google Scholar]
  • 32.Wallace D.C. Disease of the mitochondrial DNA. Ann. Rev. Biochem. 1992;61:1175–1212. doi: 10.1146/annurev.bi.61.070192.005523. [DOI] [PubMed] [Google Scholar]
  • 33.Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science. 1992;256:628–632. doi: 10.1126/science.1533953. [DOI] [PubMed] [Google Scholar]
  • 34.Bowling A.C., Mutisya E.M., Walker L.C., Price D.L., Cork L.C., Beal M.F. Age-dependent impairment of mitochondrial function in primate brain. J. Neurochem. 1993;60:1964–1967. doi: 10.1111/j.1471-4159.1993.tb13430.x. [DOI] [PubMed] [Google Scholar]
  • 35.Trounce I., Byr N.E., Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in aging. Lancet. 1989;1:637–639. doi: 10.1016/S0140-6736(89)92143-0. [DOI] [PubMed] [Google Scholar]
  • 36.Welt K., Fitz F., Schaffranietz L. Ginkgo biloba extract (EGb 761) protects ultrastructure of hypoxic myocardium in elderly rats. In: Packer L., Traber M.G., Xin W., editors. Proceedings of the International Symposium on Natural Antioxidants. Molecular Mechanisms and Health Effects. Champaign (IL): AOCS Press; 1995. pp. 424–433. [Google Scholar]
  • 37.Sastre, J., Millan, A., de la Asuncion, J.G., Pallardo, F.V., Droy-Lefaix, M.T., and Vinal, J.: Prevention of age-associated mitochondrial DNA damage by Ginkgo biloba extract EGb 761, in Proceedings of the VIII Biennial Meeting International Society for Free Radical Research, Barcelona, J.R. Prous, (in press).
  • 38.Spinnewyn B., Blavet N., Drieu K. Effect of Ginkgo biloba extract (EGb 761) on oxygen consumption by isolated cerebral mitochondria. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-related Disorders. Paris: Elsevier; 1995. pp. 17–22. [Google Scholar]
  • 39.Demopoulos H., Flamm E., Seligman M., Power R., Pietronigro D., Ransohoff J. Molecular pathology of lipids in CNS membranes. In: Jöbsis F.F., editor. Oxygen and Physiological Function. Dallas (TX): Professional Information Library; 1977. pp. 491–508. [Google Scholar]
  • 40.Pastuszko A., Gordon-Majozak W., Dabrowiecki Z. Dopamine uptake in striatal synaptosomes exposes to peroxidation “in vitro”. Biochem. Pharmacol. 1983;32:141–146. doi: 10.1016/0006-2952(83)90666-4. [DOI] [PubMed] [Google Scholar]
  • 41.Dumont E., Petit E., d’Arbigny P., Tarrade T., Nouvelot A. Ginkgo biloba extract (EGb 761) protects membrane polyunsaturated fatty acids and proteins against degradation induced by UV-C irradiation. In: Ferradini C., Droy-Lefaix M.T., Christen Y., editors. Advances in Ginkgo biloba extract, Vol. 2, Ginkgo biloba extract (EGb 761) as a free radical scavenger. Paris: Elsevier; 1993. pp. 173–184. [Google Scholar]
  • 42.Ramassamy C., Christen Y., Clostre F., Costentin J. The ginkgo biloba extract (EGb 761) increases synaptosomal uptake of 5 hydroxy tryptamine; in vitro and ex vivo studies. J. Pharm. Pharmacol. 1992;44:943–945. doi: 10.1111/j.2042-7158.1992.tb03244.x. [DOI] [PubMed] [Google Scholar]
  • 43.Huguet F., Drieu K., Tarrade T., Piriou A. Cerebral adrenergic and serotoninergic receptor loss in rats during aging can be reversed by Ginkgo biloba extract (EGb 761) In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba extract research, Vol. 4, Effects of Ginkgo biloba extract (EGb 761 ) on aging and age-related disorders. Paris: Elsevier; 1995. pp. 77–88. [Google Scholar]
  • 44.Heron D.S., Schinitzky M., Hershkowitz M., Samuel D. Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc. Natl. Acad. Sci. USA. 1980;77:7463–7467. doi: 10.1073/pnas.77.12.7463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45.Tricklebank, M.P., Forler, C., Fozard, J.R.: The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2 (din-propylamino) tretralin in the rat. Eur. J. Pharmacol., 106: 271–282. [DOI] [PubMed]
  • 46.Sram R.J., Binkova B., Stejskalova J., Topinka J. Effect of EGb 761 on lipid peroxidation, DNA repair and antioxienzyme activity. In: Ferradini C., Droy-Lefaix M.T., Christen Y., editors. Advances in Ginkgo biloba Extract Research, Vol. 2, Ginkgo biloba Extract (EGb 761) as a Free Radical Scavenger. Paris: Elsevier; 1993. pp. 27–38. [Google Scholar]
  • 47.Holgado-Madruga M., de Castro S., Macias-Nunez J.F. Effects of Ginkgo biloba extract (EGb 761) on brain aging and oxygen free-radical metabolism in the rat. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-related Disorders. Paris: Elsevier; 1995. pp. 71–76. [Google Scholar]
  • 48.Halliwell B. Oxygen radicals as key mediators in neurological disease: fact or fiction. Ann. Neurol. 1992;32:910–915. doi: 10.1002/ana.410320704. [DOI] [PubMed] [Google Scholar]
  • 49.Siesjö B.K. A new perspective of ischemic brain? In: Kogure K., Hossman K.A., Siesjö B.K., editors. Neurobiology of Ischemic Brain Damage. Amsterdam: Elsevier; 1993. pp. 1–9. [Google Scholar]
  • 50.Spinnewyn B., Blavet N., Clostre F. Effets de l’extrait de Ginkgo biloba sur un modèle d’ischémie cérébrate chez la gerbille. Presse. Med. 1986;15:1511–1515. [PubMed] [Google Scholar]
  • 51.Lavin M.F., Baxter G.D., Song Q., Findik D., Kovacs E. Protein modification in apoptosis. In: Lavin M., Watters D., editors. Programmed Cell Death, the Cellular and Molecular Biology of Apoptosis. Brisbane: Harwood Academic Pub.; 1993. pp. 45–57. [Google Scholar]
  • 52.Tomei D.L., Cope F.O. Apoptosis. The molecular basis of cell death. Current communications in cell and molecular biology. New York: Cold Spring Harbor Press; 1991. [Google Scholar]
  • 53.Slater A.F.G., Orrenius S. Oxidative stress and apoptosis. In: Cutler R.G., Packer L., Bertram J., Morri A., editors. Oxidative Stress and Aging. Basel: Birkhaüser Verlag; 1995. pp. 21–26. [Google Scholar]
  • 54.Selkoe D.J. The molecular pathology of Alzheimer’s disease. Neurons. 1991;6:487–498. doi: 10.1016/0896-6273(91)90052-2. [DOI] [PubMed] [Google Scholar]
  • 55.Buttke T.M., Sandstrom P.A. Oxidative stress as a modulator of apoptosis. Immunol. Today. 1994;15:7–10. doi: 10.1016/0167-5699(94)90018-3. [DOI] [PubMed] [Google Scholar]
  • 56.Didier A., Rouiller D., Coronas V., Jourdan F., Droy-Lefaix M.T. Effects of Ginkgo biloba extract (EGb 761) on apoptosis and regeneration of primary olfactory neurons following target “lesioning” in rats. In: Christen Y., Droy-Lefaix M.T., Macias-Nunez J.F., editors. Advances in Ginkgo biloba Extract Research, Vol. 5, Effects of Ginkgo biloba Extract (EGb 761) on Neuronal Plasticity. Paris: Elsevier; 1996. pp. 45–52. [Google Scholar]
  • 57.Del Maestro R.F., Thaw H.H., Bjork J., Planker M., Arfors K.E. Free radicals as mediators of tissue injury. Acta Physiol. Scand. 1980;492:43–57. [PubMed] [Google Scholar]
  • 58.Szabo M.E., Droy-Lefaix M.T., Doly M., Braquet P. Free radical-mediated effects in reperfusion injury: an histologic study with superoxide dismutase and EGb 761 in rat retina. Ophthalmic Res. 1991;23:225–234. doi: 10.1159/000267107. [DOI] [PubMed] [Google Scholar]
  • 59.Szabo M.E., Droy-Lefaix M.T., Doly M., Carré C., Braquet P. Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free-radical mediated mechanism. Invest. Ophthalmol. Vis. Sci. 1991;32:1471–1478. [PubMed] [Google Scholar]
  • 60.Szabo M.E., Droy-Lefaix M.T., Doly M., Braquet P. Modification of ischemia-reperfusion-induced ion shifts (Na+, K+, Ca2+, Mg2+) Ophthalmic Res. 1993;25:1–9. doi: 10.1159/000267214. [DOI] [PubMed] [Google Scholar]
  • 61.Menerath J.M., Cluzel J., Droy-Lefaix M.T., Doly M. Electroretinographic assessment of a free radical scavenger (EGb 761) treatment on rat retinal ischemia. Invest. Ophthalmol. Vis. Sci. 1995;36:S934. [Google Scholar]
  • 62.Menerath J.M., Doly M., Droy-Lefaix M.T., Besse G., Vennat J. Evaluation electroretinographique et histologique de l’ischémie rétinienne chez le rat par hypertonie intra-oculaire. Ophtalmologie. 1995;9:291–300. [Google Scholar]
  • 63.Behar-Cohen F.F., Heydolph S., Faure V., Droy-Lefaix M.T., Courtois Y., Goureau O. Peroxynitrite cytotoxicity on bovine retinal pigmented epithelial cells in culture. Biochem. Biophys. Res. Comm. 1996;226:842–849. doi: 10.1006/bbrc.1996.1438. [DOI] [PubMed] [Google Scholar]
  • 64.Droy-Lefaix M.T., Bonhomme B., Doly M. A protective effect of EGb 761 on aging rat retina. Invest. Ophthalmol. Vis. Sci. 1995;36:S855. [Google Scholar]
  • 65.Esterbauer H., Gebicki J., Puhl H., Jürgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad. Biol. Med. 1992;13:341–390. doi: 10.1016/0891-5849(92)90181-F. [DOI] [PubMed] [Google Scholar]
  • 66.Fortun A., Khalil A., Bonnefont-Rousselot D., Gardès-Albert M., Lepage S., Delattre J., Droy-Lefaix M.T. Effect of EGb 761 on the peroxidation of human low-density lipoproteins (LDL) initiated by oxyradicals generated by water radiolysis. J. Chim. Phys. 1994;91:1078–1084. [Google Scholar]
  • 67.McCord J.M. Oxygen-derived free radicals in post ischemic tissue injury. N. Engl. J. Med. 1985;312:159–163. doi: 10.1056/NEJM198501173120305. [DOI] [PubMed] [Google Scholar]
  • 68.Blasig I.E., Ebert B., Hennig C., Pali T., Tosaki A. Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart. Cardiovasc. Res. 1990;24:263–270. doi: 10.1093/cvr/24.4.263. [DOI] [PubMed] [Google Scholar]
  • 69.Terada L.S., Rubinstein J.D., Lesnefsky E.J., Horwitz L.D., Left J.A., Repine J.E. Existence and participation of xanthine-oxidase in reperfusion injury of ischemic rabbit myocardium. Am. J. Physiol. 1991;260:H805–H810. doi: 10.1152/ajpheart.1991.260.3.H805. [DOI] [PubMed] [Google Scholar]
  • 70.Packer L., Haramaki N., Kawabata T., Marcocci L., Maitra I., Maguire J.J., Droy-Lefaix M.T., Sekaki A.H., Gardès-Albert M. Ginkgo biloba extract (EGb 761); antioxidant action and prevention of oxidative stress-induced injury. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-related Disorders. Paris: Elsevier; 1995. pp. 23–47. [Google Scholar]
  • 71.Packer L. Oxidative stress, antioxidants aging and disease. In: Cutler R.G., Packer L., Bertram J., Morri A., editors. Oxidative Stress and Aging. Basel: Birkhaüser Verlag; 1995. pp. 1–14. [Google Scholar]
  • 72.Culcasi M., Pietri S., Carriere I., d’Arbigny P., Drieu K. Electron-spin-resonance study of the protective effects of Ginkgo biloba extract (EGb 761) on reperfusion-induced free radical generation associated with plasma ascorbate consumption during open-out surgery in man. In: Ferradini C., Droy-Lefaix M.T., Christen Y., editors. Advances in Ginkgo biloba Extract Research, Vol. 2, Ginkgo biloba Extract (EGb 761) as a Free Radical Scavenger. Paris: Elsevier; 1993. pp. 153–162. [Google Scholar]
  • 73.Taillandier J., Ammar A., Rabourdin J.P., Ribeyre J.P., Pichon J., Niddam S., Pierart H. Ginkgo biloba extract in the treatment of cerebral disorders due to aging. Longitudinal, multicenter, double-blind study versus placebo. In: Fünfgeld E.W., editor. Rökan (Ginkgo biloba) Recent Results in Pharmacology and Clinic. Berlin: Springer-Verlag; 1988. pp. 291–301. [Google Scholar]
  • 74.Allain, H., Lieury, A., Gandon, J.M., and d’Arbigny, P.: The dual-coding test in elderly subjects: psychometric assessment of properties of Ginkgo biloba extract (EGb 761), in Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-Related Disorders, edited by Christen, Y., Courtois, Y., and Droy-Lefaix, M.T., Paris, Elsevier, pp. 131–139.
  • 75.Israël L., Myslinski M., Dell’Accio E., Lambert C., Hugonot R. Onset of memory disorders: specific and combined contributions of memory-training programs and Ginkgo biloba extract (EGb 761) treatment. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-Related Disorders. Paris: Elsevier; 1995. pp. 119–129. [Google Scholar]
  • 76.Hofferberth B. Influence of Ginkgo biloba Extract (EGb 761) on neurophysiological and neuropsychological measurements in patients suffering from psychoorganic syndrome. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-Related Disorders. Paris: Elsevier; 1995. pp. 141–148. [Google Scholar]
  • 77.Kanowski S. Proof of efficacy of the Ginkg biloba special extract (EGb 761) in outpatients suffering from primary degenerative dementia of the Alzheimer type and multi-infarct dementia. In: Christen Y., Courtois Y., Droy-Lefaix M.T., editors. Advances in Ginkgo biloba Extract Research, Vol. 4, Effects of Ginkgo biloba Extract (EGb 761) on Aging and Age-Related Disorders. Paris: Elsevier; 1995. pp. 149–158. [Google Scholar]

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