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. 2005 Dec;31(3-4):243–248. doi: 10.1007/s10867-005-7285-4

Single Macromolecules: Hierarchic Thermodynamics, Irreversibility and Biological Function

Kenichi Yoshikawa 1,✉
PMCID: PMC3456320  PMID: 23345896

Abstract

Single homo-polymers show two different paths in the folding transition; a liquid-like spherical globule is generated for flexible polymers, whereas a rich variety of ordered structures are formed for semi-flexible polymers. This unique characteristic is discussed in relation to its biological significance.

Key words: giant DNA, coil-globule transition, DNA condensation, genetic switching, genetic regulation

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