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Journal of Biological Physics logoLink to Journal of Biological Physics
. 2003 Jun;29(2-3):117–121. doi: 10.1023/A:1024476322147

Terahertz Time-Domain Spectroscopy of Glucose and Uric Acid

PC Upadhya 1, YC Shen 1, AG Davies 2, EH Linfield 1
PMCID: PMC3456418  PMID: 23345826

Abstract

We report the use ofterahertz time-domain spectroscopy for thestudy of two therapeutic bio-molecules:glucose and uric acid. Terahertztransmission spectra of crystalline samplesof both molecules were measured between 0.1–3.0 THz using an evacuated spectroscopysystem. We propose that the stereo-isomersof glucose show spectral featuresoriginating from intermolecular vibrationalmodes, as do uric acid and its derivativemolecule, allantoin. In addition, wepresent a full temperature dependence ofthe terahertz absorption of L-glucose.

Keywords: Glucose, intermolecular, temperature dependent absorption, terahertz, time-domain spectroscopy, uric acid

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