Abstract
We introduce a simplified protein model where the water degrees of freedom appear explicitly (although in an extremely simplified fashion). Using thismodel we are able to recover both the warm and the cold protein denaturation within a single framework, while addressing important issues about the structure of model proteins.
Keywords: Cold denaturation, hydrophobic forces, proteins
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Contributor Information
G. Caldarelli, Email: gcalda@pil.phys.uniroma1.it
P. De Los Rios, Email: Paolo.DeLosRios@ipt.unil.ch
References
- 1.Lau K.F., Dill K.A. Macromolecules. 1989;22:3986. [Google Scholar]
- 2.Vanderzande C. Lattice Models of Polymers. Cambridge: Cambbridge University Press; 1998. [Google Scholar]
- 3.Kauzmann W. Adv. Protein Chem. 1959;14:1. doi: 10.1016/s0065-3233(08)60608-7. [DOI] [PubMed] [Google Scholar]
- 4.Murphy K.P., Privalov P.L., Gill S.J. Science. 1999;247:559. doi: 10.1126/science.2300815. [DOI] [PubMed] [Google Scholar]
- 5.Privalov P.L., Gill S.J. Adv. Protein Chem. 1988;39:191. doi: 10.1016/s0065-3233(08)60377-0. [DOI] [PubMed] [Google Scholar]
- 6.Pace N.C., Tanford C. Biochemistry. 1968;7:198. doi: 10.1021/bi00841a025. [DOI] [PubMed] [Google Scholar]
- 7.Franks H.S., Evans M.W. J. Chem. Phys. 1945;13:507. [Google Scholar]
- 8.Muller N. Acc. Chem. Res. 1990;23:23. [Google Scholar]
- 9.Lee B., Graziano G. J. Am. Chem. Soc. 1996;22:5163. [Google Scholar]
- 10.Silverstein K.A.T., Haymet A.D.J., Dill K.A. J. Am. Chem. Soc. 1998;120:3166. [Google Scholar]
- 11.Silverstein K.A.T., Haymet A.D.J., Dill K.A. J. Chem. Phys. 1999;111:8000. [Google Scholar]
- 12.Miyazawa S., Jernigan R.L. J. Mol. Biol. 1996;256:623. doi: 10.1006/jmbi.1996.0114. [DOI] [PubMed] [Google Scholar]
- 13.Vendruscolo M., Domany E. J. Chem. Phys. 1998;109:11101. [Google Scholar]
- 14.Seno F., Micheletti C., Maritan A., Banavar J.R. Phys. Rev. Lett. 1998;81:2172. [Google Scholar]
- 15.Banavar J.R., Maritan A. Proteins. 2001;42:433. [PubMed] [Google Scholar]
- 16.San Biagio P.L., Bulone D., Martorana V., Palma-Vittorelli D.B., Palma M.U. Eur. Biophys. J. 1998;27:183. [Google Scholar]
- 17.Park K., Vendruscolo M., Domany E. Proteins. 2000;40:237. [PubMed] [Google Scholar]
