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. 2001 Jun;27(2-3):147–159. doi: 10.1023/A:1013151530254

Energy Profile of the Space of Model Protein Sequences

G Tiana 1,3, RA Broglia 1,3, EI Shakhnovich 2
PMCID: PMC3456584  PMID: 23345740

Abstract

A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.

Keywords: energy landscapes, model protein, space of sequences

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