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. 1982 Jan;79(2):267–271. doi: 10.1073/pnas.79.2.267

Imported mitochondrial proteins cytochrome b2 and cytochrome c1 are processed in two steps.

S M Gasser, A Ohashi, G Daum, P C Böhni, J Gibson, G A Reid, T Yonetani, G Schatz
PMCID: PMC345707  PMID: 7043457

Abstract

Cytochrome b2 of yeast is located in the space between the inner and outer mitochondrial membranes whereas cytochrome c1 is bound to the outer face of the mitochondrial inner membrane. Both proteins are made outside the mitochondria as larger precursors that are processed to their mature forms in two steps. In the first step, at least a segment of the precursor polypeptide chain penetrates into the mitochondrial matrix and is cleaved to an intermediate form by a matrix-localized soluble protease. This step requires an electrochemical gradient across the mitochondrial inner membrane. In the second step, the intermediate form is converted to the mature form. For cytochrome c1, this second step requires heme. Import of these two cytochromes thus involves a "detour" across the inner membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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