Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1982 Jan;79(2):555–558. doi: 10.1073/pnas.79.2.555

Inverted repeat nucleotide sequences in the genomes of Marek disease virus and the herpesvirus of the turkey.

J Cebrian, C Kaschka-Dierich, N Berthelot, P Sheldrick
PMCID: PMC345783  PMID: 6281774

Abstract

The DNAs of two herpesvirus, the oncogenic Marek disease virus and the serologically related herpesvirus of the turkey, were studied by electron microscopy. On the basis of fold-back molecules observed in single-stranded DNA from both viruses, structures have been derived from the overall nucleotide sequence arrangement in their genomes. Although differing in molecular weight, the genomes of Marek disease virus and turkey herpesvirus are both constructed according to the same plan--two regions of unique nucleotide sequence, each enclosed by inverted repeat sequence. The genome structure of these viruses therefore closely resembles that of herpes simplex virus rather than the biologically more similar herpesvirus Epstein--Barr virus, H. saimiri, and H. ateles.

Full text

PDF
555

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akiyama Y., Kato S. Two cell lines from lymphomas of Marek's disease. Biken J. 1974 Sep;17(3):105–116. [PubMed] [Google Scholar]
  2. Ben-Porat T., Rixon F. J., Blankenship M. L. Analysis of the structure of the genome of pseudorabies virus. Virology. 1979 Jun;95(2):285–294. doi: 10.1016/0042-6822(79)90484-7. [DOI] [PubMed] [Google Scholar]
  3. Bornkamm G. W., Delius H., Fleckenstein B., Werner F. J., Mulder C. Structure of Herpesvirus saimiri genomes: arrangement of heavy and light sequences in the M genome. J Virol. 1976 Jul;19(1):154–161. doi: 10.1128/jvi.19.1.154-161.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Buchman T. G., Roizman B. Anatomy of bovine mammillitis DNA II. Size and arrangements of the deoxynucleotide sequences. J Virol. 1978 Jul;27(1):239–254. doi: 10.1128/jvi.27.1.239-254.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Delius H., Clements J. B. A partial denaturation map of herpes simplex virus type 1 DNA: evidence for inversions of the unique DNA regions. J Gen Virol. 1976 Oct;33(1):125–133. doi: 10.1099/0022-1317-33-1-125. [DOI] [PubMed] [Google Scholar]
  6. Desgranges C., Wolf H., De-Thé G., Shanmugaratnam K., Cammoun N., Ellouz R., Klein G., Lennert K., Muñoz N., Zur Hausen H. Nasopharyngeal carcinoma. X. Presence of epstein-barr genomes in separated epithelial cells of tumours in patients from Singapore, Tunisia and Kenya. Int J Cancer. 1975 Jul 15;16(1):7–15. doi: 10.1002/ijc.2910160103. [DOI] [PubMed] [Google Scholar]
  7. Fleckenstein B., Bornkamm G. W., Mulder C., Werner F. J., Daniel M. D., Falk L. A., Delius H. Herpesvirus ateles DNA and its homology with Herpesvirus saimiri nucleic acid. J Virol. 1978 Jan;25(1):361–373. doi: 10.1128/jvi.25.1.361-373.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fleckenstein B. Oncogenic herpesviruses of non-human primates. Biochim Biophys Acta. 1979 Nov 30;560(3):301–342. doi: 10.1016/0304-419x(79)90007-6. [DOI] [PubMed] [Google Scholar]
  9. Given D., Kieff E. DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B95-8 and W91 strains of Epstein-Barr Virus. J Virol. 1978 Nov;28(2):524–542. doi: 10.1128/jvi.28.2.524-542.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Given D., Kieff E. DNA of Epstein-Barr virus. VI. Mapping of the internal tandem reiteration. J Virol. 1979 Aug;31(2):315–324. doi: 10.1128/jvi.31.2.315-324.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Given D., Yee D., Griem K., Kieff E. DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA. J Virol. 1979 Jun;30(3):852–862. doi: 10.1128/jvi.30.3.852-862.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Grafstrom R. H., Alwine J. C., Steinhart W. L., Hill C. W. Terminal repetitions in herpes simplex virus type 1 DNA. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):679–681. doi: 10.1101/sqb.1974.039.01.081. [DOI] [PubMed] [Google Scholar]
  13. Hayward G. S., Jacob R. J., Wadsworth S. C., Roizman B. Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4243–4247. doi: 10.1073/pnas.72.11.4243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hirai K., Ikuta K., Kato S. Comparative studies on Marek's disease virus and herpesvirus of turkey DNAs. J Gen Virol. 1979 Oct;45(1):119–131. doi: 10.1099/0022-1317-45-1-119. [DOI] [PubMed] [Google Scholar]
  15. Kaschka-Dierich C., Bornkamm G. W., Thomssen R. No homology detectable between Marek's disease virus (MDV) DNA and herpesvirus of the turkey (HVT) DNA. Med Microbiol Immunol. 1979 Jan 24;165(4):223–239. doi: 10.1007/BF02152922. [DOI] [PubMed] [Google Scholar]
  16. Kawamura H., King D. J., Jr, Anderson D. P. A herpesvirus isolated from kidney cell culture of normal turkeys. Avian Dis. 1969 Nov;13(4):853–863. [PubMed] [Google Scholar]
  17. Klein G. Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc Natl Acad Sci U S A. 1979 May;76(5):2442–2446. doi: 10.1073/pnas.76.5.2442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lee L. F., Kieff E. D., Bachenheimer S. L., Roizman B., Spear P. G., Burmester B. R., Nazerian K. Size and composition of Marek's disease virus deoxyribonucleic acid. J Virol. 1971 Mar;7(3):289–294. doi: 10.1128/jvi.7.3.289-294.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Lindahl T., Adams A., Bjursell G., Bornkamm G. W., Kaschka-Dierich C., Jehn U. Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line. J Mol Biol. 1976 Apr 15;102(3):511–530. doi: 10.1016/0022-2836(76)90331-4. [DOI] [PubMed] [Google Scholar]
  20. Miller G. Epstein-Barr herpesvirus and infectious mononucleosis. Prog Med Virol. 1975;20:84–112. [PubMed] [Google Scholar]
  21. Nazerian K., Lee L. F. Deoxyribonucleic acid of Marek's disease virus in a lymphoblastoid cell line from Marek's disease tumours. J Gen Virol. 1974 Nov;25(2):317–321. doi: 10.1099/0022-1317-25-2-317. [DOI] [PubMed] [Google Scholar]
  22. Nazerian K. Marek's disease lymphoma of chicken and its causative herpesvirus. Biochim Biophys Acta. 1979 Nov 30;560(3):375–395. doi: 10.1016/0304-419x(79)90010-6. [DOI] [PubMed] [Google Scholar]
  23. Payne L. N., Frazier J. A., Powell P. C. Pathogenesis of Marek's disease. Int Rev Exp Pathol. 1976;16:59–154. [PubMed] [Google Scholar]
  24. Pettersson U., Mulder C., Deluis H., Sharp P. A. Cleavage of adenovirus type 2 DNA into six unique fragments by endonuclease R-RI. Proc Natl Acad Sci U S A. 1973 Jan;70(1):200–204. doi: 10.1073/pnas.70.1.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Powell P. C., Payne L. N., Frazier J. A., Rennie M. T lymphoblastoid cell lines from Marek's disease lymphomas. Nature. 1974 Sep 6;251(5470):79–80. doi: 10.1038/251079a0. [DOI] [PubMed] [Google Scholar]
  26. Roizman B. The structure and isomerization of herpes simplex virus genomes. Cell. 1979 Mar;16(3):481–494. doi: 10.1016/0092-8674(79)90023-0. [DOI] [PubMed] [Google Scholar]
  27. Ross L. J., Basarab O., Walker D. J., Whitby B. Serological relationship between a pathogenic strain of Marek's disease virus, its attenuated derivative and herpes virus of turkeys. J Gen Virol. 1975 Jul;28(1):37–47. doi: 10.1099/0022-1317-28-1-37. [DOI] [PubMed] [Google Scholar]
  28. Sanger F., Air G. M., Barrell B. G., Brown N. L., Coulson A. R., Fiddes C. A., Hutchison C. A., Slocombe P. M., Smith M. Nucleotide sequence of bacteriophage phi X174 DNA. Nature. 1977 Feb 24;265(5596):687–695. doi: 10.1038/265687a0. [DOI] [PubMed] [Google Scholar]
  29. Sheldrick P., Berthelot N. Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):667–678. doi: 10.1101/sqb.1974.039.01.080. [DOI] [PubMed] [Google Scholar]
  30. Sheldrick P., Laithier M., Lando D., Ryhiner M. L. Infectious DNA from herpes simplex virus: infectivity of double-stranded and single-stranded molecules. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3621–3625. doi: 10.1073/pnas.70.12.3621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Skare J., Summers W. C. Structure and function of herpesvirus genomes. II. EcoRl, Sbal, and HindIII endonuclease cleavage sites on herpes simplex virus. Virology. 1977 Feb;76(2):581–595. doi: 10.1016/0042-6822(77)90240-9. [DOI] [PubMed] [Google Scholar]
  32. Stevely W. S. Inverted repetition in the chromosome of pseudorabies virus. J Virol. 1977 Apr;22(1):232–234. doi: 10.1128/jvi.22.1.232-234.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Tanaka A., Silver S., Nonoyama M. Biochemical evidence of the nonintegrated status of Marek's disease virus DNA in virus-transformed lymphoblastoid cells of chicken. Virology. 1978 Jul 1;88(1):19–24. doi: 10.1016/0042-6822(78)90105-8. [DOI] [PubMed] [Google Scholar]
  34. Wadsworth S., Jacob R. J., Roizman B. Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions. J Virol. 1975 Jun;15(6):1487–1497. doi: 10.1128/jvi.15.6.1487-1497.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Wagner M. J., Summers W. C. Structure of the joint region and the termini of the DNA of herpes simplex virus type 1. J Virol. 1978 Aug;27(2):374–387. doi: 10.1128/jvi.27.2.374-387.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Werner F. J., Bornkamm G. W., Fleckenstein B. Episomal viral DNA in a Herpesvirus saimiri-transformed lymphoid cell line. J Virol. 1977 Jun;22(3):794–803. doi: 10.1128/jvi.22.3.794-803.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Wilkie N. M., Cortini R. Sequence arrangement in herpes simplex virus type 1 DNA: identification of terminal fragments in restriction endonuclease digests and evidence for inversions in redundant and unique sequences. J Virol. 1976 Oct;20(1):211–221. doi: 10.1128/jvi.20.1.211-221.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Wilkie N. M. Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad. J Virol. 1976 Oct;20(1):222–233. doi: 10.1128/jvi.20.1.222-233.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Witter R. L., Nazerian K., Purchase H. G., Burgoyne G. H. Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. Am J Vet Res. 1970 Mar;31(3):525–538. [PubMed] [Google Scholar]
  40. Witter R. L., Sharma J. M., Offenbecker L. Turkey herpesvirus infection in chickens: induction of lymphoproliferative lesions and characterization of vaccinal immunity against Marek's disease. Avian Dis. 1976 Oct-Dec;20(4):676–692. [PubMed] [Google Scholar]
  41. de-Thé G., Geser A., Day N. E., Tukei P. M., Williams E. H., Beri D. P., Smith P. G., Dean A. G., Bronkamm G. W., Feorino P. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature. 1978 Aug 24;274(5673):756–761. doi: 10.1038/274756a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES