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. 1982 Feb;79(3):884–888. doi: 10.1073/pnas.79.3.884

Specific cellular stimulation in the primary immune response: experimental test of a quantized model.

R Z Dintzis, B Vogelstein, H M Dintzis
PMCID: PMC345857  PMID: 6950432

Abstract

Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.

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Selected References

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