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. 1982 Feb;79(3):908–911. doi: 10.1073/pnas.79.3.908

Abnormal polyunsaturated fatty acid patterns of serum lipids in Reye's syndrome.

P L Ogburn Jr, H Sharp, J D Lloyd-Still, S B Johnson, R T Holman
PMCID: PMC345862  PMID: 6950433

Abstract

Fatty acid patterns of the serum lipids were measured in 17 children with Reye's syndrome (RS). Serial measurements of total serum free fatty acids (FFA) showed that levels were increased during RS and, after recovery, were significantly lower in the patients who survived. Fatty acid patterns of serum FFA, triglycerides, and phospholipids in patients with RS were significantly different from those in controls. In RS the polyunsaturated fatty acid content of phospholipids was less than control values; in the FFA, it was higher. This was consistent with the possible involvement of increased phospholipase activity. The increase in polyunsaturated fatty acids in FFA, the precursors of prostaglandins, suggests that a grossly disturbed prostaglandin pattern may occur in RS. These changes in lipid metabolism may be related to the abnormal hepatic and neurological functions observed in RS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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