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. 1982 Feb;79(4):1042–1044. doi: 10.1073/pnas.79.4.1042

Beta-endorphin: replacement of tyrosine in position 27 by tryptophan increases analgesic potency--preparation and properties of the 2-nitrophenylsulfenyl derivative.

C H Li, D Yamashiro, P Nicolas
PMCID: PMC345895  PMID: 6280164

Abstract

An analog of human beta-endorphin with tryptophan in position 27 has been synthetized by the solid-phase method. Bioassay of the analog showed that it had almost 4 times the analgesic potency of the parent hormone but only 68% of the opiate receptor-binding activity. The peptide is the most potent analgesic among the known synthetic analogs of beta-endorphin. The 2-nitrophenylsulfenyl derivative of the analog has been prepared and shown to have a lower analgesic potency and a higher opiate receptor-binding activity than the parent compound.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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