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. 1982 Feb;79(4):1225–1229. doi: 10.1073/pnas.79.4.1225

At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.

H L Robinson, B M Blais, P N Tsichlis, J M Coffin
PMCID: PMC345934  PMID: 6280174

Abstract

Recombinants of oncogenic and nononcogenic avian leukosis viruses were tested for their oncogenic potential in chickens. The results indicate that at least two regions of the viral genome determine the oncogenic potential of these viruses. The first region contains sequences that control viral mRNA synthesis. These sequences determine the potential of a virus to induce a low incidence of lymphomas, carcinomas, chondrosarcomas, fibrosarcomas, and osteopetrosis. The second region lies outside the sequences that control viral mRNAs synthesis. These sequences determine the ability of a virus to induce a high incidence of lymphomas or osteopetrosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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