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. 1982 Mar;79(6):1984–1988. doi: 10.1073/pnas.79.6.1984

Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.

J Ellison, L Hood
PMCID: PMC346106  PMID: 6804948

Abstract

We report the nucleotide sequence of a gene encoding a human immunoglobulin C gamma 2 region. Comparison with the previously determined C gamma 4 sequence reveals that these two genes share extensive (approximately 95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favored the generation of diversity in these coding regions. We have used the noncoding nucleotide differences to estimate that approximately 6-7 million years have elapsed since the occurrence of the gene duplication or correction event which generated the two identical ancestral genes. In addition we show that the two C gamma genes are arranged in human chromosomal DNA in the configuration 5'-C gamma 2-17 kilobase pairs -C gamma 4-3'.

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1984

Selected References

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